835916-04-6 Usage
Description
(S)-1-CBZ-AMINO-2-BOC-AMINO-3-PHENYL-PROPANE is a chemical compound derived from proline, a naturally occurring amino acid. It features a benzyl carbamate (CBZ) protecting group on the amino group at the first position and a tert-butoxycarbonyl (BOC) protecting group on the amino group at the second position. Additionally, the third position of the compound is occupied by a phenyl group. (S)-1-CBZ-AMINO-2-BOC-AMINO-3-PHENYL-PROPANE is utilized as a building block in the synthesis of more complex organic molecules and has potential applications in various fields, including organic synthesis, pharmaceuticals, and biotechnology.
Uses
Used in Organic Synthesis:
(S)-1-CBZ-AMINO-2-BOC-AMINO-3-PHENYL-PROPANE is used as a building block for the synthesis of complex organic molecules. Its unique structure, with protecting groups and a phenyl group, allows for the creation of a wide range of compounds with diverse properties and applications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (S)-1-CBZ-AMINO-2-BOC-AMINO-3-PHENYL-PROPANE is used as an intermediate in the development of new drugs. Its specific properties and reactivity make it a valuable component in the synthesis of pharmaceutical compounds, potentially leading to the discovery of novel therapeutic agents.
Used in Biotechnology:
(S)-1-CBZ-AMINO-2-BOC-AMINO-3-PHENYL-PROPANE also has potential applications in biotechnology. It can be employed in the design and synthesis of bioactive molecules, such as peptides and proteins, which can be used in various biotechnological applications, including drug discovery, diagnostics, and therapeutics.
Check Digit Verification of cas no
The CAS Registry Mumber 835916-04-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,3,5,9,1 and 6 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 835916-04:
(8*8)+(7*3)+(6*5)+(5*9)+(4*1)+(3*6)+(2*0)+(1*4)=186
186 % 10 = 6
So 835916-04-6 is a valid CAS Registry Number.
InChI:InChI=1/C22H28N2O4/c1-22(2,3)28-21(26)24-19(14-17-10-6-4-7-11-17)15-23-20(25)27-16-18-12-8-5-9-13-18/h4-13,19H,14-16H2,1-3H3,(H,23,25)(H,24,26)/t19-/m1/s1
835916-04-6Relevant articles and documents
Insertion of an aspartic acid moiety into cyclic pseudopeptides: Synthesis and biological characterization of potent antagonists for the human tachykinin NK-2 receptor
Fedi, Valentina,Altamura, Maria,Balacco, Giuseppe,Canfarini, Franca,Criscuoli, Marco,Giannotti, Danilo,Giolitti, Alessandro,Giuliani, Sandro,Guidi, Antonio,Harmat, Nicholas J. S.,Nannicini, Rossano,Pasqui, Franco,Patacchini, Riccardo,Perrotta, Enzo,Tramontana, Manuela,Triolo, Antonio,Maggi, Carlo Alberto
, p. 6935 - 6947 (2007/10/03)
A new series of monocyclic pseudopeptide tachykinin NK-2 receptor antagonists has been derived from the lead compound MEN11558. A synthesis for these molecules sharing the same intermediate was designed and performed. The replacement of the succinic moiety with an aspartic acid and the functionalization of its amino group with a wide variety of substituents led to very potent and selective NK-2 antagonists. Best results were obtained through the insertion in position 12 of an amino group with R configuration, linked by a short spacer to a saturated nitrogen heterocycle (morpholine, piperidine, or piperazine). The study led to compounds 54 and 57, endowed with high in vivo potency at very low doses and long duration of action in animal models of bronchoconstriction. In particular 54 and 57 completely inhibited NK-2 agonist induced bronchoconstriction in guinea pig after intratracheal administration at subnanomolar doses (ED50 = 0.27 nmol/kg and 0.15 nmol/kg, respectively).
