835922-48-0

Upstream product

• 6627-88-9 4-allyl-2,6-dimethoxyphenol 
• 487-11-6 elemicin 
• 487-12-7 isoelemicin 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 657393-37-8 (1S,2S)-1-(3,4,5-trimethoxyphenyl)propane-1,2-diol 
• 20675-95-0 (E)-2,6,-dimethoxy-4-(prop-1-en-1-yl)phenol 
• 16603-18-2 (3,4,5-trimethoxyphenyl)acetone 
• 638990-30-4 (R)-3-(3,4,5-trimethoxyphenyl)-1,2-propanediol 
• 5438-54-0 1,3-dimethoxy-2-[(prop-2-en-1-yl)oxy]benzene 
• 91-10-1 1,3-dimethoxy-2-hydroxy-benzene 
• 835922-47-9 (R)-3-(3,4,5-trimethoxyphenyl)-1-O-tosyl-1,2-propanediol 

Downstream Products

• 860294-69-5 (R)-3,5-dimethoxy-4-[1-methyl-2-(3,4,5-trimethoxyphenyl)ethoxyl]benzaldehyde 

Relevant academic research and scientific papers

Concise access toward chiral hydroxy phenylpropanoids: formal synthesis of virolongin B; kigelin; kurasoin A; 4-hydroxysattabacin, and actinopolymorphol A

A simple, two step strategy consisting of Sharpless asymmetric dihydroxylation followed by regioselective breaking of [Formula presented] bond is utilized to target key chiral intermediates of natural products virolongin B, kigelin, kurasoin A, 4-hydroxy-sattabacin, and actinopolymorphol A. Derivatives of enantiopure hydroxy phenyl propanoids and α-hydroxy Weinreb amides are synthesized. The reductive cleavage of [Formula presented] bond in a regioselective manner is obtained using Pd/C in methanol.

Chemoenzymatic synthesis of enantiomerically pure syn-configured 1-aryl-3-methylisochroman derivatives

A two-step synthesis of various enantiomerically pure 1-aryl-3- methylisochroman derivatives was accomplished through asymmetric biocatalytic ketone reduction followed by an oxa-Pictet-Spengler reaction. The compounds were obtained in good to excellent yield (47-92 %) in favor of the syn diastereomers [dr (syn/anti) up to 99:1]. Enantiopure arylpropanols serving as pronucleophiles for the C-C bond-formation step were obtained by biocatalytic reduction by employing enantiocomplementary alcohol dehydrogenases, which gave access to the (S) and (R) enantiomer with up to >99 % conversion and up to >99 % ee. A two-step sequence involving a biocatalytic hydrogen-transfer reduction and a syn-diastereoselective oxa-Pictet-Spengler reaction was established to provide a series of 1-aryl-3-methylchroman derivatives with perfect enantioselectivity; PTSA = para-toluenesulfonic acid. Copyright

First enantioselective synthesis of the neolignans Rhaphidecursinol A and Virolongin B

The enantioselective synthesis of the neolignans Rhaphidecursinol A and Virolongin B is reported for the first time. The key reactions in the synthesis were Sharpless asymmetric dihydroxylation and Mitsunobu reaction. The absolute configuration of Rhaphidecursinol A was confirmed.