835926-53-9Relevant academic research and scientific papers
Synthesis, preliminary biological evaluation and molecular modeling of some new heterocyclic inhibitors of TACE
Sengupta, Prabal,Puri, Chetan S.,Chokshi, Hemant A.,Sheth, Chetana K.,Midha, Ajay S.,Chitturi, Trinadha Rao,Thennati, Rajamannar,Murumkar, Prashant R.,Yadav, Mange Ram
, p. 5549 - 5555 (2011/12/15)
Central heteroaryl ring analogues belonging to a series of potent hydroxamate TACE inhibitors were synthesized. The TACE inhibitory activities of these compounds were evaluated by in vitro WBA and in silico molecular modeling studies using crystal structure of human TACE. Compound 14 showed very good in vitro inhibition, supported by the in silico docking studies.
5-Amidinobenzo[b]thiophenes as dual inhibitors of factors IXa and Xa
Qiao, Jennifer X.,Cheng, Xuhong,Modi, Dilip P.,Rossi, Karen A.,Luettgen, Joseph M.,Knabb, Robert M.,Jadhav, Prabhakar K.,Wexler, Ruth R.
, p. 29 - 35 (2007/10/03)
Syntheses and SAR studies of 5-amidinobenzo[b]thiophene analogs provided compounds with low submicromolar factor IXa potency and equal or slightly better selectivity relative to factor Xa. Syntheses and SAR studies of 5-amidinobenzo[b]thiophene analogs provided compounds with low submicromolar factor IXa activity and equal or slightly better selectivity relative to factor Xa.
