835929-53-8Relevant academic research and scientific papers
Enantioselective Modular Total Synthesis of Macrolides Sch725674 and C-4-epi-Sch725674
Sharma, Brijesh M.,Gontala, Arjun,Kumar, Pradeep
, p. 1215 - 1226 (2016)
The convergent total synthesis of Sch725674 has been accomplished by starting from (R)-1,2-epoxyheptane and assembling five modules in a highly stereoselective manner to give the final product in 6.6 % overall yield. The same strategy was extended to the
A concise and efficient stereoselective synthesis of the C1-C11 fragment of macrolactin A
Bonini, Carlo,Chiummiento, Lucia,Videtta, Valeria,Colobert, Fran?oise,Solladié, Guy
, p. 2427 - 2430 (2008/02/10)
A stereoselective synthesis of the C1-C11 fragment of macrolactin A, using original approaches for the introduction of the Z,E-diene stereochemistry and the C-7 stereogenic center, is reported. The adopted strategy has allowed us to build up the fragment
Design, synthesis, and evaluation of carbamate-substituted analogues of (+)-discodermolide
Smith III, Amos B.,Freeze, B. Scott,LaMarche, Matthew J.,Hirose, Tomoyasu,Brouard, Ignacio,Rucker, Paul V.,Xian, Ming,Sundermann, Kurt F.,Shaw, Simon J.,Burlingame, Mark A.,Horwitz, Susan Band,Myles, David C.
, p. 311 - 314 (2007/10/03)
(Chemical Equation Presented) The design, syntheses, and biological evaluation of 22 totally synthetic analogues of the potent microtubule- stabilizing agent (+)-discodermolide (1) have been achieved. Structure-activity relationships of the C(19) carbamat
Design, synthesis, and evaluation of analogues of (+)-14- normethyldiscodermolide
Smith III, Amos B.,Freeze, B. Scott,LaMarche, Matthew J.,Hirose, Tomoyasu,Brouard, Ignacio,Xian, Ming,Sundermann, Kurt F.,Shaw, Simon J.,Burlingame, Mark A.,Horwitz, Susan Band,Myles, David C.
, p. 315 - 318 (2007/10/03)
(Chemical Equation Presented) The design, syntheses, and biological evaluation of nine totally synthetic analogues of the microtubule-stabilizing agent (+)-14-normethyldiscodermolide (2) are reported. Simplification at the C(21)-C(24) terminal diene and a
