836-27-1Relevant articles and documents
5-Alkylresorcinol derivatives from the bryozoan Schizomavella mamillata: Isolation, synthesis, and antioxidant Activity
Ortega, María J.,Pantoja, Juan J.,De Los Reyes, Carolina,Zubía, Eva
, (2017)
The chemical study of the bryozoan Schizomavella mamillata has led to the isolation of six new 5-alkylresorcinol derivatives, schizols A–F (1–6), whose structures were established by spectrocospic means. Schizol A (1) exhibits a (E)-6-phenylnon-5-enyl moi
Enantioselective intramolecular friedel-crafts-type α-arylation ofaldehydes
Nicolaou, K. C.,Reingruber, Ruediger,Sarlah, David,Braese, Stefan
supporting information; experimental part, p. 2086 - 2087 (2009/07/30)
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Δ9-tetrahydrocannabinol immunochemical studies: Haptens, monoclonal antibodies, and a convenient synthesis of radiolabeled Δ9-tetrahydrocannabinol
Qi, Longwu,Yamamoto, Noboru,Meijler, Michael M.,Altobell III, Laurence J.,Koob, George F.,Wirsching, Peter,Janda, Kim D.
, p. 7389 - 7399 (2007/10/03)
Immunopharmacotherapy as an approach to combat drugs of abuse has become an active area of investigation. Marijuana is the most commonly used illicit drug in the U.S. The main active chemical in marijuana is Δ9- tetrahydrocannabinol (Δ9-THC); hence, monoclonal antibodies with high affinity and specificity for Δ9-tetrahydrocannabinol could be valuable immunopharmacotherapeutic intervention and diagnostic tools. We have synthesized immunoconjugates that induce an effective immune response to Δ9-THC and describe a convenient synthesis of radiolabeled Δ9-THC. We demonstrate the value and use of this probe to select anti-Δ9-THC antibodies that bind Δ9-THC with good affinity. The synthetic route to radiolabeled Δ9-THC has enabled the correct assessment of the affinity of these antibodies to their ligand and may facilitate future binding studies between Δ9- THC and its analogues and the cannabinoid receptors.