83607-51-6

Upstream product

• 83607-48-1 2,3,4,4a,6,7-hexahydro-6,10-dimethoxy-1H,5,11b-ethanodibenzazepine 
• 1885-14-9 phenyl chloroformate 

Downstream Products

• 83607-52-7 3a-<5-Methoxy-2-(2,4-dinitrophenylhydrazonoethyl)phenyl>hexahydro-1-indolinecarboxylic acid phenyl ester 
• 83607-53-8 4-methoxy-2-(1-methylhexahydroindolin-3a-yl)phenethyl alcohol 

Relevant academic research and scientific papers

Skeletal Rearrangement of 3-Methoxy-N-chloromorphinan

3-Methoxymorphinan (1) was converted to the corrsponding N-chloro derivative 2 by tratment with aqueous sodium hypochlorite.Upon exposure to methanolic silver nitrate, 2 was rearranged to the carbinolamine ether 3.In addition, considerable amounts of the dechlorinated morphinan 1 were formed.The structure of 3 was secured by spectral analysis and its degradation to the hexahydroindoline derivative 4.The observed skeletal rearrangement of 2 which requires the migration of an alkyl group is discussed in terms of a netrenium ion.