83634-04-2

Basic information

• Product Name: 5-Benzyl-2,3,5,6-tetrahydroimidazo[2,1-a]isoquinolin-5-ol
• Synonyms: 5-Benzyl-2,3,5,6-tetrahydroimidazo[2,1-a]isoquinolin-5-ol
• CAS NO: 83634-04-2
• Molecular Formula: C₁₈H₁₈N₂O
• Molecular Weight: 278.3483
• Mol File: 83634-04-2.mol

Chemical Properties

• Boiling Point: 460.2°Cat760mmHg
• Flash Point: 232.1°C
• Appearance: /
• Density: 1.22g/cm³
• Vapor Pressure: 2.89E-09mmHg at 25°C
• Refractive Index: 1.66
• CAS DataBase Reference: 5-Benzyl-2,3,5,6-tetrahydroimidazo[2,1-a]isoquinolin-5-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Benzyl-2,3,5,6-tetrahydroimidazo[2,1-a]isoquinolin-5-ol(83634-04-2)
• EPA Substance Registry System: 5-Benzyl-2,3,5,6-tetrahydroimidazo[2,1-a]isoquinolin-5-ol(83634-04-2)

Safety Data

• Hazardous Substances Data: 83634-04-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C18H18N2O/c21-18(12-14-6-2-1-3-7-14)13-15-8-4-5-9-16(15)17-19-10-11-20(17)18/h1-9,21H,10-13H2

Upstream product

• 101-41-7 benzeneacetic acid methyl ester 
• 57327-93-2 2-(o-Tolyl)-2-imidazoline 

Relevant articles and documents

Antidepressant activity of 5-aryl-2,3,5,6-tetrahydroimidazo[2,1-a]isoquinolin-5-ols

A series of 5-aryl-2,3,5,6-tetrahydroimidazo[2,1-a]isoquinolin-5-ols was prepared and evaluated for potential antidepressant activity in the reserpine-induced hypothermia model and selected central nervous system and autonomic activity tests. Several members of the series, notably the 4-chloro- and 4-fluorophenyl analogues, demonstrated pharmacological activity in the range of imipramine. Both compounds provided a marked potentiation of the 5-hydroxytryptophan-facilitated monosynaptic spike in the spinal cat preparation.

Directed Lithiation of 2-Phenyl- and 2-(o-Methylphenyl)imidazoline

2-Phenyl- and 2-(o-methylphenyl)imidazoline have been converted into their ortho- and α-lithiated species, respectively, by treatment with n-BuLi-hexane in THF.Treatment of these reagents with a variety of nucleophiles gave ortho- and α-substituted products.