83641-62-7

Upstream product

• 4457-32-3 4-nitrobenzyl chloroformate 
• 83641-61-6 (3S*,4R*)-1-tert-butyldimethylsilyl-3-<(R*)-1-tert-butyldimethylsilyloxyethyl>-4-(2-propynyllithium)-2-azetidinone 

Downstream Products

• 74288-37-2 4-nitrobenzyl (2R*,3S*)-1-tert-butyldimethylsilyl-3-<(R*)-1-tert-butyldimethylsilyloxyethyl>-4,β-dioxo-2-azetidinebutyrate 
• 83641-63-8 (Z)-4-{(2R,3S)-1-(tert-Butyl-dimethyl-silanyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-3-phenylsulfanyl-but-2-enoic acid 4-nitro-benzyl ester 
• 83641-63-8 (Z)-4-{(2R,3S)-1-(tert-Butyl-dimethyl-silanyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-3-phenylsulfanyl-but-2-enoic acid 4-nitro-benzyl ester 

Relevant academic research and scientific papers

A MILD METHOD FOR THE CONVERSION OF PROPIOLIC ESTERS TO β-KETO ESTERS. APPLICATION TO THE FORMAL TOTAL SYNTHESIS OF (+/-)-THIENAMYCIN

An extremely mild method for the transformation of propiolic esters to β-keto esters via thiol addition is reported, including its succesful application to the synthesis of (+/-)-thienamycin.