83642-24-4

Upstream product

• 680-31-9 N,N,N,N,N,N-hexamethylphosphoric triamide 
• 1073-72-9 4-hydroxythioanisole 
• 1194-02-1 4-fluorobenzonitrile 

Downstream Products

• 21120-66-1 p-[p-(methylthio)phenoxy]-benzoic acid 
• 501375-64-0 2-[2-(4-methylthio)phenoxy-3-pyridyl]-4H-1,3-benzothiazine-4-one 

Relevant academic research and scientific papers

NOVEL GLUCOCORTICOID RECEPTOR AGONISTS

This invention relates to novel glucocorticoid receptor agonists of formula (I) and to processes and intermediates for their preparation. The present invention also relates to pharmaceutical compositions containing these compounds, to their combination with one or more other therapeutic agents, as well as to their use for the treatment of a number of inflammatory and allergic diseases, disorders and conditions.

Sulfur-substituted diphenyl ethers having antiviral activity

Novel compounds exhibiting antiviral activity are disclosed, such compounds are represented by the formula: STR1 wherein m represents the integer 0, 1 or 2; R represents trihalomethyl, alkyl or phenyl; R1 represents hydrogen, bromo, chloro, fluoro, cyano, nitro, amino, alkyl, alkoxy or trifluoromethyl; R2 represents hydroxyl, bromo, chloro, fluoro, cyano, acetyl, benzoyl, substituted benzoyl, alkyl, alkoxy, substituted alkoxy, benzyl, substituted benzyl, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl, or the radical --O(CH2)n R4 wherein n represents the integer 1, 2 or 3 and R4 represents cyano or dialkylamino; R3 represents hydrogen, hydroxyl, bromo, chloro, fluoro, cyano, acetyl, benzoyl, substituted benzoyl, alkyl, alkoxy, substituted alkoxy, benzyl, substituted benzyl, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl, or the radical --O(CH2)n R4 wherein n represents the integer 1, 2 or 3; and R4 represents cyano or dialkylamino; or alternatively R2 and R3 taken together represent the radical --O--C(X)2 --O-- wherein X represents hydrogen, bromo, chloro or fluoro. Methods of using the above-noted compounds and structurally related compounds to employ their antiviral activity are also disclosed as well as pharmaceutically-acceptable compositions.