83651-49-4

Upstream product

• 113564-20-8 (E)-(2S,6R)-7-(tert-Butyl-dimethyl-silanyloxy)-2,6-dimethyl-hept-4-enoic acid 
• 83651-47-2 (2S,6R)-7-(tert-Butyl-dimethyl-silanyloxy)-2,6-dimethyl-heptanoic acid 
• 83651-45-0 (2S^*,3S^*)-1-<(tert-butyldimethylsilyl)oxy>-2-methyl-4-penten-3-yl propanoate 
• 83651-44-9 (2S^*,3S^*)-1-<(tert-butyldimethylsilyl)oxy>-2-methyl-4-penten-3-ol 
• 90107-04-3 (2S^*,3S^*)-2-methyl-4-pentene-1,3-diol 
• 83651-48-3 (2S,6R)-7-(tert-Butyl-dimethyl-silanyloxy)-2,6-dimethyl-heptan-1-ol 
• 98-59-9 p-toluenesulfonyl chloride 
• 83651-46-1 (E)-7-(tert-Butyl-dimethyl-silanyloxy)-2,6-dimethyl-hept-4-enoic acid 
• 83651-47-2 7-(tert-Butyl-dimethyl-silanyloxy)-2,6-dimethyl-heptanoic acid 
• 83651-45-0 Propionic acid 1-[2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-allyl ester 
• 83651-44-9 5-(tert-Butyl-dimethyl-silanyloxy)-4-methyl-pent-1-en-3-ol 
• 83651-48-3 7-(tert-Butyl-dimethyl-silanyloxy)-2,6-dimethyl-heptan-1-ol 
• 42411-90-5 (S)-2-Methyl-pent-4-ene-1,3-diol 
• 83651-41-6 (4R^*,5S^*)-5-hydroxy-2,4-dimethyl-2-<(trimethylsilyl)oxy>-6-hepten-3-one 

Relevant academic research and scientific papers

1,4- and 1,5-Stereoselection by Sequential Aldol Addition to α,β-Unsaturated Aldehydes Followed by Claisen Rearrangement. Application to Total Synthesis of the Vitamin E Side Chain and the Archaebacterial C40 Diol

A synthetic strategy has been developed wherein the high 1,2-stereoselection obtainable from aldol reaction of an α,β-unsaturated aldehyde is parlayed by a subsequent Claisen rearrangement into 1,4- or 1,5-stereoselection.For example, diol monoethers 26 a

ACYCLIC STEREOSELECTION. 15. SEQUENTIAL ALDOL-CLAISEN AS A METHOD FOR 1,5-STEREOSELECTION. TOTAL SYNTHESIS OF THE VITAMIN-E SIDE CHAIN

Alcohol 1, the side chain of α-tocopherol, has been synthesized in a stereoselective route involving an aldol condensation-Claisen rearrangement sequence.The synthesis requires 11 steps and produces 1 in 17percent overall yield.A complementary sequence em