836599-03-2

Upstream product

• 994-30-9 triethylsilyl chloride 
• 474524-59-9 2-(2'-bromoethyl)-5,6-dihydro-2H-pyran 
• 474524-58-8 (3R,4R)-6-(tert-butyldiphenylsilyloxy)-3-methyl-4-(triethylsilyloxy)hexanal 
• 836598-94-8 (Z)-1-(tert-butyldimethylsilyloxy)-7-(tosyloxy)hept-4-en-3-ol 
• 474524-60-2 1-(tert-butyldimethylsilyloxy)-7-(trimethylsilyloxy)hept-4-yn-3-ol 
• 836598-93-7 7-(tert-butyldimethylsilyloxy)hept-3-yn-1,5-diol 
• 474524-61-3 (Z)-7-(tert-butyldimethylsilyloxy)hept-3-ene-1,5-diol 
• 474524-69-1 2-(2'-tosyloxyethyl)-5,6-dihydro-2H-pyran 
• 474524-62-4 2-[(2-tert-butyldimethylsilyloxy)ethyl]-5,6-dihydro-2H-pyran 
• 350986-60-6 (+)-(3R,4R)-6-(t-butyldiphenylsilyloxy)-4-(triethylsilyloxy)-3-methylhexan-1-ol 
• 350986-59-3 (+)-(3R,4R)-6-(t-butyldiphenylsilyloxy)-4-(triethylsilyloxy)-3-methylhex-1-ene 
• 86611-27-0 2-(2'-hydroxyethyl)-5,6-dihydro-2H-pyran 

Downstream Products

• 836599-05-4 (3R,5R,6R)-8-(tert-butyldiphenylsilyloxy)-1-(5,6-dihydro-2H-pyran-2-yl)-5-methyloctane-3,6-diol 

Relevant academic research and scientific papers

Synthesis of the 1,6,8-trioxadispiro[4.1.5.2]tetradec-11-ene ring system present in the spirolide family of shellfish toxins and its conversion into a 1,6,8-trioxadispiro[4.1.5.2]-tetradec-9-en-12-ol via base-induced rearrangement of an epoxide

The synthesis of the 1,6,8-trioxadispiro[4.1.5.2]tetradec-11-enes 12 present in the shellfish toxins spirolides B 1 and D 2, is reported. The two spirocentres were constructed via iterative radical oxidative cyclization of hydroxyalkyl dihydropyran 14 and