836611-13-3Relevant academic research and scientific papers
Sequential C-H activation enabled expedient delivery of polyfunctional arenes
Cai, Xiaoqing,Chen, Qian,Chen, Xiaojian,Gao, Yang,Huo, Yanping,Li, Xianwei,Ouyang, Wensen,Rao, Jianhang,Wang, Jie
supporting information, p. 8075 - 8078 (2021/08/20)
Modular construction of polyfunctional arenes from abundant feedstocks stands as an unremitting pursue in synthetic chemistry, accelerating the discovery of drugs and materials. Herein, using the multiple C-H activation strategy with versatile imidate esters, the expedient delivery of molecular libraries of densely functionalized sulfur-containing arenes was achieved, which enabled the concise construction of biologically active molecules, such as Bipenamol.
Efficient discovery of potent anti-HIV agents targeting the Tyr181Cys variant of HIV reverse transcriptase
Jorgensen, William L.,Bollini, Mariela,Thakur, Vinay V.,Domaoal, Robert A.,Spasov, Krasimir A.,Anderson, Karen S.
supporting information; experimental part, p. 15686 - 15696 (2011/12/03)
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) that interfere with the replication of human immunodeficiency virus (HIV) are being pursued with guidance from molecular modeling including free-energy perturbation (FEP) calculations for protein-in
Unusual oxidative dehydration of vic-[alkyl(aryl)thio]-substituted aromatic (heteroaromatic) carboxamides
Kislitsyn,Kucherov,Chukhrov,Zlotin,Starikova,Dolgushin
, p. 916 - 924 (2007/10/03)
A new procedure was developed for the synthesis of nitriles of vic-[alkyl(aryl)sulfonyl] derivatives of benzoic, anthraquinonecarboxylic, and 4-isothiazolecarboxylic acids by the reactions of the corresponding vic-[alkyl(aryl)thio]-substituted aromatic (h
Selective Inhibitors of Monoamine Oxidase. 2. Arylamide SAR
Harfenist, Morton,Joyner, Charles T.,Mize, Patrick D.,White, Helen L.
, p. 2085 - 2089 (2007/10/02)
Monoamine oxidase (MAO) exists in two forms distinguishable by substrate specificity.Inhibition of MAO A is believed to be responsible for the antidepressant activity of MAO inhibitors.A group of N-arylacetamides are highly specific inhibitors of MAO A, some with IC50 values in the 10-100 nM range.The requirements for high activity and specificity include a nearly linear tricyclic aromatic portion but a larger and a smaller central ring component.The amide group, which is best acetamido, is optimally placed para to the smaller central group.The size and shape of the aromatic moiety appear to be the major influence on activity and specificity for MAO A.
