836612-94-3

Upstream product

• 836612-84-1 (S)-N-Allyl-2-((S)-2-but-3-enyloxycarbonylamino-3-methyl-butyrylamino)-succinamic acid methyl ester 
• 836612-87-4 (E)-(4S,7S)-4-Isopropyl-2,5,9-trioxo-1-oxa-3,6,10-triaza-cyclopentadec-12-ene-7-carboxylic acid methyl ester 
• 709674-74-8 N-allyl-2-tert-butoxycarbonylamino-succinamic acid methyl ester 
• 709674-75-9 N-((but-3-en-1-yloxy)carbonyl)-L-valine 
• 364635-77-8 tert-butyl (1S,2S,4R)-5-({(1S)-1-[(benzylamino)carbonyl]-2-methylpropyl}amino)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-isobutyl-4-methyl-5-oxopentylcarbamate 
• 6306-52-1 L-valine methylester hydrochloride 
• 30293-86-8 methyl (S)-(-)-2-isocyanato-3-methylbutyrate 
• 836612-92-1 (2R,4S,5S)-5-Amino-4-(tert-butyl-dimethyl-silanyloxy)-2,7-dimethyl-octanoic acid ((S)-1-benzylcarbamoyl-2-methyl-propyl)-amide 

Relevant academic research and scientific papers

Structure-based design of cycloamide-urethane-derived novel inhibitors of human brain memapsin 2 (β-secretase)

A series of novel macrocyclic amide-urethanes was designed and synthesized based upon the X-ray crystal structure. Inhibitors containing 14- to 16-membered rings exhibited low nanomolar inhibitory potencies against memapsin 2. A series of novel macrocycli