836683-15-9

Usage

Uses

Used in Pharmaceutical Industry:
Acumapimod (BCT-197) is used as a therapeutic agent for the treatment of inflammatory diseases and disorders, such as rheumatoid arthritis, chronic obstructive pulmonary disease (COPD), and fibrotic conditions. Its ability to inhibit the p38 MAP kinase enzyme helps in reducing inflammation and fibrosis, offering potential benefits to patients suffering from these conditions.
Used in Research and Development:
Acumapimod (BCT-197) is used as a research tool in preclinical and early clinical trials to evaluate its efficacy and safety in treating inflammatory and fibrotic conditions. Ongoing research aims to further explore its potential applications and optimize its therapeutic use in diverse inflammatory and fibrotic diseases.

Upstream product

• 2458-12-0 3-amino-p-toluic acid 
• 21667-63-0 3-(2-cyanoacetyl)benzonitrile 
• 765-30-0 Cyclopropylamine 
• 836682-66-7 3-[5-amino-4-(3-iodo-benzoyl)-pyrazol-1-yl]-N-cyclopropyl-4-methyl-benzamide 

Relevant academic research and scientific papers

SYNTHETIC METHOD FOR THE PREPARATION OF A 3-[5-AMINO-4-(3-CYANOBENZOYL)-PYRAZOL COMPOUND

Provided is a process for preparing a compound, comprising the steps of a) Reacting a compound of Formula A (Formula A) with the compound 3 (3) to provide the compound 5 (5) or a salt or solvate thereof, wherein R is a linear or branched C1-C5 alkyl. Further provided is the compound 5 or a salt or solvate thereof. (5) The use of these compounds in the synthesis of 3-[5-Amino-4-(3- Cyanobenzoyl)-Pyrazol-1-yl]-N-Cyclopropyl-4-Methylbenzamide is also provided.

SYNTHETIC METHOD FOR THE PREPARATION OF AN HYDRAZINE COMPOUND

Provided is a process for preparing the compound 3 (3) or a salt or a solvate thereof, the process comprising the steps of a) Mixing the compound 4 with a mineral acid (4); b) Adding a nitrite salt or an organic nitrite derivative to the reaction mass to form a diazonium salt; c) Adding a sulfur-containing reducing agent to the reaction mass to form a hydrazyl sulfur complex, such as a hydrazyl sulfite complex; d) Hydrolysing the hydrazyl sulfur complex to provide the compound 3 or a salt or solvate thereof; and e) Optionally isolating the compound 3 or a salt or solvate thereof. Further provided is the use of the compound 3 in the synthesis of 3-[5-Amino-4- (3-Cyanobenzoyl)-Pyrazol-1-yl]-N-Cyclopropyl-4-Methylbenzamide.

SYNTHETIC METHODFOR THE PREPARATION OF AN ALKOXYMETHYLENE-BENZOYLACETONITRILE

Provided is a process for preparing a compound of Formula A (Formula A) or a salt or solvate thereof, the process comprising the step of: a) Reacting the compound 1 (1) with a trialkyl orthoformate to provide a compound of Formula A or a salt or solvate thereof, wherein R is the alkyl moiety of the trialkyl orthoformate. Further provided is the compound 2 or a salt or solvate thereof. (2) The use of these compounds in the synthesis of 3-[5-Amino-4-(3- Cyanobenzoyl)-Pyrazol-1-yl]-N-Cyclopropyl-4-Methylbenzamide is also provided.

5-MEMBERED HETEROCYCLE-BASED P38 KINASE INHIBITORS

Provided are 5-membered heterocycle-based p38 kinase inhibitors. Further provided are pyrazole and imidazole-based p38 kinase, including p38α and p38β kinase, inhibitors. Pharmaceutical compositions containing the compounds are also provided. Methods of u