83680-31-3

Basic information

• Product Name: Butanoic acid, 4-oxo-2-[(tetrahydro-2H-pyran-2-yl)oxy]-, phenylmethyl ester, (2S)-
• CAS NO: 83680-31-3
• Molecular Formula: C16H20O5
• Molecular Weight: 292.332
• Mol File: 83680-31-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Butanoic acid, 4-oxo-2-[(tetrahydro-2H-pyran-2-yl)oxy]-, phenylmethyl ester, (2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 4-oxo-2-[(tetrahydro-2H-pyran-2-yl)oxy]-, phenylmethyl ester, (2S)-(83680-31-3)
• EPA Substance Registry System: Butanoic acid, 4-oxo-2-[(tetrahydro-2H-pyran-2-yl)oxy]-, phenylmethyl ester, (2S)-(83680-31-3)

Safety Data

• Hazardous Substances Data: 83680-31-3(Hazardous Substances Data)

Upstream product

• 77856-36-1 (S)-4-Hydroxy-2-(tetrahydro-pyran-2-yloxy)-butyric acid benzyl ester 
• 77856-36-1 4-Hydroxy-2-(tetrahydro-pyran-2-yloxy)-butyric acid benzyl ester 
• 110-87-2 3,4-dihydro-2H-pyran 
• 56881-91-5 (S)-3-(Tetrahydro-pyran-2-yloxy)-dihydro-furan-2-one 
• 56881-91-5 3-(Tetrahydro-pyran-2-yloxy)-dihydro-furan-2-one 

Downstream Products

• 77856-41-8 (S)-4-((S)-2-Oxo-tetrahydro-furan-3-ylamino)-2-(tetrahydro-pyran-2-yloxy)-butyric acid benzyl ester 
• 860795-17-1 (S)-1-{(S)-3-Benzyloxycarbonyl-3-[(S)-3-benzyloxycarbonyl-3-(tetrahydro-pyran-2-yloxy)-propylamino]-propyl}-azetidine-2-carboxylic acid 
• 848785-47-7 (S)-1-[(S)-3-Benzyloxycarbonyl-3-((S)-3-benzyloxycarbonyl-3-hydroxy-propylamino)-propyl]-azetidine-2-carboxylic acid 
• 77856-44-1 (S)-2-{[(S)-3-Benzyloxycarbonyl-3-(tetrahydro-pyran-2-yloxy)-propyl]-tert-butoxycarbonyl-amino}-4-oxo-butyric acid benzyl ester 
• 77856-43-0 (S)-2-{[(S)-3-Benzyloxycarbonyl-3-(tetrahydro-pyran-2-yloxy)-propyl]-tert-butoxycarbonyl-amino}-4-hydroxy-butyric acid benzyl ester 
• 77856-42-9 (S)-4-[tert-Butoxycarbonyl-((S)-2-oxo-tetrahydro-furan-3-yl)-amino]-2-(tetrahydro-pyran-2-yloxy)-butyric acid benzyl ester 
• 77856-47-4 (S)-1-((S)-3-Benzyloxycarbonyl-3-{[(S)-3-benzyloxycarbonyl-3-(tetrahydro-pyran-2-yloxy)-propyl]-tert-butoxycarbonyl-amino}-propyl)-azetidine-2-carboxylic acid benzyl ester 
• 77856-44-1 2-{[3-Benzyloxycarbonyl-3-(tetrahydro-pyran-2-yloxy)-propyl]-tert-butoxycarbonyl-amino}-4-oxo-butyric acid benzyl ester 
• 77856-43-0 2-{[3-Benzyloxycarbonyl-3-(tetrahydro-pyran-2-yloxy)-propyl]-tert-butoxycarbonyl-amino}-4-hydroxy-butyric acid benzyl ester 
• 77856-42-9 4-[tert-Butoxycarbonyl-(2-oxo-tetrahydro-furan-3-yl)-amino]-2-(tetrahydro-pyran-2-yloxy)-butyric acid benzyl ester 

Relevant articles and documents

A short practical synthesis of 2′-deoxymugineic acid

A short and practical synthesis of 2′-deoxymugineic acid (DMA) has been developed via reductive alkylation with the aldehyde intermediates. No protection of azetidine-2-carboxylic acid was required and the presence of free carboxylic acid function facilitated purification by simple acid and base extractions. Furthermore, the intermediates were conveniently purified by HPLC due to the presence of chromophoric benzyl ester protecting group(s). Hydrogenolysis of the benzyl protecting groups in the final step furnished DMA in overall good yield.