83695-12-9Relevant academic research and scientific papers
EASY AND EFFICIENT SNAr REACTIONS ON HALOPYRIDINES IN SOLVENT FREE CONDITIONS
Loupy, Andre,Philippon, Noelle,Pigeon, Phillippe,Galons, Herve
, p. 1947 - 1953 (2007/10/02)
Solid-liquid phase transfer catalysis (PTC) without added solvent efficiently promotes SNAr reactions on halopyridines with a variety of anionic nucleophiles generated in situ.This metodology gives access to substituted pyridines in very simplified conditions depending on halide nature.Mechanistic investigations are proposed.
