83703-39-3Relevant academic research and scientific papers
Synthesis of (1′S*,2R*,3R*)- and (1′S*,2R*,3S*)-N-arylsulfonyl-2-(1′-halogenethyl)-3-methylindolines and their selective toxicity against SH-SY5Y cell line
Gataullin, Rail R.,Maksimova, Marina A.,Vakhitova, Yuliya V.,Zainullina, Liana F.,Zileeva, Zulfia R.
, (2020/01/24)
N-tosyl-2- and N-tosyl-4-halogen-substituted derivatives of 2-(1-methylbut-2-en-1-yl)aniline were synthesized and their molecular iodine-mediated cyclization was investigated. The cyclization upon interaction of N-tosyl-6-methyl-2-(1-methylbut-2-en-1-yl)a
Approach to preparative synthesis of ortho-(1-methylbut-2-en-1-yl)anilines, precursors of new cytotoxic heterocycles
Aleksandrova,Abdullin,Vakhitova, Yu. V.,Gataullin
, p. 810 - 814 (2016/06/13)
The reaction of aromatic Claisen rearrangement of N-(1-methylbut-2-en-1-yl)anilines in the presence of p-toluenesulfonic acid was investigated. N-Tosyl-2-(1-iodoethyl)-3-methylindoline derivatives were obtained; one of them exhibited a cytotoxic activity.
EFFECTS OF SUBSTITUENTS IN ACID-CATALYZED CLAISEN AMINO REARRANGEMENT
Abdrakhmanov, I. B.,Saraeva, Z. N.,Nigmatullin, N. G.,Komissarov, V. D.,Tolstikov, G. A.
, p. 2117 - 2122 (2007/10/02)
A series of 4-R2-N-R1-N-(1-methyl-2-butenyl)- and 4-R2-N-R1-2-(1-methyl-2-butenyl)-anilines was synthesized.The rate constants of rearrangement and elimination of the hydrochlorides of the 4-R2-N-R1-N-(1-methyl-2-butenyl)anilines in nitrobenzene were measured at 110 and 130 deg C.The correlation equations which describe the effect of the nature of the substituents on the reactivity of the substrate in these reactions and the selectivity of their occurence were established.A mechanism of the processes was proposed.
