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Selenazofurin is a synthetic nucleoside analog that functions as a potent and selective inhibitor of the enzyme inosine monophosphate dehydrogenase (IMPDH), which plays a crucial role in the de novo synthesis of guanosine nucleotides. Selenazofurin has demonstrated anti-proliferative and anti-tumor effects in various cancer cell lines by disrupting the biosynthesis of guanine nucleotides, essential for DNA and RNA synthesis. Its specificity for IMPDH and potential as a therapeutic agent for certain types of cancer, especially those with elevated IMPDH activity, make selenazofurin a promising candidate for further research and clinical applications.

83705-13-9

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83705-13-9 Usage

Uses

Used in Oncology:
Selenazofurin is used as an anti-cancer agent for its ability to inhibit IMPDH, thereby disrupting the biosynthesis of guanine nucleotides in cancer cells. This action leads to anti-proliferative and anti-tumor effects, making it a potential treatment for certain types of cancer with elevated IMPDH activity.
Used in Pharmaceutical Research:
Selenazofurin is used as a research tool to study the role of guanine nucleotide biosynthesis in various biological processes. Its specificity for IMPDH allows scientists to investigate the enzyme's function and its implications in cancer development and other diseases.
Used in Drug Development:
Selenazofurin is being explored for its potential in the development of new therapeutic agents for cancer treatment. Its mechanism of action and selectivity for IMPDH make it a valuable compound for designing targeted cancer therapies, with ongoing research aimed at optimizing its clinical efficacy and safety.

Check Digit Verification of cas no

The CAS Registry Mumber 83705-13-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,3,7,0 and 5 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 83705-13:
(7*8)+(6*3)+(5*7)+(4*0)+(3*5)+(2*1)+(1*3)=129
129 % 10 = 9
So 83705-13-9 is a valid CAS Registry Number.
InChI:InChI=1/C9H12N2O5Se/c10-8(15)3-2-17-9(11-3)7-6(14)5(13)4(1-12)16-7/h2,4-7,12-14H,1H2,(H2,10,15)

83705-13-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3-selenazole-4-carboxamide

1.2 Other means of identification

Product number -
Other names Selenazofurin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:83705-13-9 SDS

83705-13-9Downstream Products

83705-13-9Relevant academic research and scientific papers

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