83706-98-3

Usage

Uses

Used in Pharmaceutical Industry:
4,4,4-Trifluorobut-2-enol (cis) is used as a key intermediate in the synthesis of pharmaceuticals for its ability to introduce fluorine atoms into drug molecules, which can enhance the drug's potency, selectivity, and metabolic stability.
Used in Agrochemical Industry:
In the agrochemical industry, 4,4,4-Trifluorobut-2-enol (cis) is utilized as a precursor in the production of fluorinated agrochemicals, which can improve the effectiveness and selectivity of these compounds in pest control and crop protection.
Used in Organic Chemistry:
4,4,4-Trifluorobut-2-enol (cis) is employed as a reagent in various organic chemistry reactions, particularly in the preparation of fluorinated compounds. Its unique structure allows for selective fluorination and functional group transformations, making it a valuable tool in organic synthesis.
Used in Fluorinated Chemicals and Materials Production:
Due to its properties, 4,4,4-Trifluorobut-2-enol (cis) is a valuable building block for the production of a wide range of fluorinated chemicals and materials, including specialty polymers, surfactants, and other performance chemicals.
It is important to handle and store 4,4,4-Trifluorobut-2-enol (cis) with care due to its flammability and potential health hazards, ensuring safety in its applications across various industries.

Upstream product

• 674-35-1 4,4,4-Trifluor-2-iod-buten-(2)-ol-(1) 
• 25597-16-4 ethyl 4,4,4-trifluorobut-2-enoate 
• 75-63-8 Bromotrifluoromethane 
• 107-19-7 propargyl alcohol 
• 2314-97-8 iodotrifluoromethane 
• 728040-39-9 4,4,4-trifluorobutenol acetate 

Downstream Products

• 286836-16-6 1-(1-trifluoromethylprop-1-en-3-yloxy)-2-bromo-4-fluorobenzene 
• 871917-92-9 4,4,4-trifluoro-2-butenyl p-toluenesulfonate 
• 406-88-2 4,4,4-trifluorocrotonaldehyde 
• 1536-55-6 γ-Trifluormethylallyl-p-brombenzolsulfonat 

Relevant academic research and scientific papers

Practical synthesis of 4,4,4-trifluorocrotonaldehyde: A versatile precursor for the enantioselective formation of trifluoromethylated stereogenic centers via organocatalytic 1,4-additions

The practical synthesis of 4,4,4-trifluorocrotonaldehyde (1) and its application to enantioselective 1,4-additions are described. The organocatalytic 1,4-addition of 1 with several nucleophiles such as heteroaromatics, alkylthiols and aldoximes afforded t

PROCESS FOR PREPARING 2-OXO-1-PYRROLIDINE DERIVATIVES BY INTRAMOLECULAR ALLYLATION

The present invention relates to a new process for preparing 2-oxo-1-pyrrolidine derivatives of general formula (I), comprising the cyclisation of an intermediate of general formula (II) wherein the substituents are as defined in the specification.

Ultrasound-Promoted Selective Perfluoroalkylation on the Desired Position of Organic Molecules

Perfluoroalkylzinc iodides or bromides wich were prepared from perfluoroalkyl iodides or bromides and zinc powder in N,N-dimethylformamide or tetrahydrofuran with ultrasonic irradiation were found to behave as potential perfluoroalkylating reagents for the preparation of a wide variety of perfluoroalkylated compounds.Especially, the ultrasound-promoted asymmetric induction with perfluoroalkyl group on the asymmetrical carbon was achieved by the reaction of perfluoroalkyl halides with optically active enamines in the presence of zinc powder and a catalytic amount of dichlorobis(?-cyclopentadienyl)titanium.

PREPARATION OF TRIFLUOROMETHYLATED ALLYLIC ALCOHOLS FROM TRIFLUOROACETALDEHYDE AND ORGANOMETALLIC COMPOUNDS

A number of allylic alcohols bearing a trifluoromethyl group at the α- or γ-position, and α-trifluoromethylated γ-enols and -ynols were prepared by the reaction of trifluoroacetaldehyde with a variety of organometallic compounds.Most of the Reformatsky- or Grignard-type reactions required promotion by ultrasonic irradiation.

ULTRASOUND-PROMOTED HYDRPERFLUOROALKYLATION OF ALKYNES WITH PERFLUOROALKYLZINC IODIDE AND COPPER(I) IODIDE

The reaction of perfluoroalkyl iodides with terminal alkynes and ultrasonically dispersed zinc in the presence of copper(I) iodide proceeded smoothly to give the corresponding vinyl perfluoroalkylides in good yields.