83718-63-2Relevant academic research and scientific papers
A concise, stereoselective synthesis of picenadol
Martinelli, Michael J.,Peterson, Barry C.
, p. 5401 - 5404 (2007/10/02)
A four-step stereoselective synthesis of picenadol (1) is reported, 1,3-Dimethyl-4-piperidone (3) underwent Horner-Wadsworth-Emmons reaction under conditions that did not yield double-bond isomerization, followed by a directed 1,4-addition with an aryl cuprate. Reduction and deprotection then afforded (1).
