837371-89-8

Basic information

• Product Name: 5-(1-oxy-pyridin-4-yl)-3-[3-cyano-4-{2-(2-methoxyethoxy)ethoxy}phenyl]-1,2,4-triazole
• Synonyms: 5-(1-oxy-pyridin-4-yl)-3-[3-cyano-4-{2-(2-methoxyethoxy)ethoxy}phenyl]-1,2,4-triazole
• CAS NO: 837371-89-8
• Molecular Weight: 381.391
• Mol File: 837371-89-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-(1-oxy-pyridin-4-yl)-3-[3-cyano-4-{2-(2-methoxyethoxy)ethoxy}phenyl]-1,2,4-triazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(1-oxy-pyridin-4-yl)-3-[3-cyano-4-{2-(2-methoxyethoxy)ethoxy}phenyl]-1,2,4-triazole(837371-89-8)
• EPA Substance Registry System: 5-(1-oxy-pyridin-4-yl)-3-[3-cyano-4-{2-(2-methoxyethoxy)ethoxy}phenyl]-1,2,4-triazole(837371-89-8)

Safety Data

• Hazardous Substances Data: 837371-89-8(Hazardous Substances Data)

Upstream product

• 6975-73-1 1-oxide pyridine-4-carbohydrazide 
• 837371-97-8 3-cyano-4-{2-(2-methoxyethoxy)ethoxy}benzonitrile 

Relevant articles and documents

PROCESS FOR PRODUCING 1,2,4-TRIAZOLE COMPOUND AND INTERMEDIATE THEREFOR

Provided is a process for producing 1,2,4-triazole compound (5), or a salt or hydrate thereof which comprises reacting compound (1) with Rc-X (2) to give compound (3), reacting compound (3) with a nitrilization agent to give compound (4), and then removing the group Rc, as shown by the reaction scheme: (Wherein Ra, Rb and Rd represent a group, Rc represents a group which can be removed by an acid) A 1,2,4-triazole compound (5) having an optionally substituted 2-cyanopyridin-4-yl group at 3-position and an optionally substituted aromatic group at 5-position which inhibits a xanthine oxidase and is useful for treatment of gout and hyperuricemia can be obtained from compound (1) in a high yield without requiring isolation of reaction products in the course of reactions.