837383-75-2

Upstream product

• 1550-35-2 2,4-difluorobenzaldehyde 
• 137-07-5 2-amino-benzenethiol 
• 136-95-8 2-amino-benzthiazole 
• 288101-48-4 2-(2,4-difluorophenyl)-4,4, 5,5-tetramethyl-1,3,2-dioxaborolane 
• 615-20-3 2-chlorobenzo[d][1,3]thiazole 
• 95-16-9 1,3-Benzothiazole 
• 2265-93-2 2,4-difluoro-1-iodobenzene 
• 56456-47-4 2,4-difluorobenzyl alcohol 

Downstream Products

• 656821-57-7 2-(benzo[d]thiazol-2-yl)-3,5-difluorophenol 

Relevant academic research and scientific papers

An economic, simple and convenient synthesis of 2-aryl/heteroaryl/styryl/alkylbenzothiazoles using SiO2-HNO3

The present work was undertaken to develop an economic method for the synthesis of 2-aryl/heteroaryl/styryl/alkylbenzothiazoles mediated by SiO2-HNO3. In this report, we have demonstrated the catalytic potential of SiO2-HN

Synthesis of some benzothiazoles by developing a new protocol using urea nitrate as a catalyst and their antimicrobial activities

The present communication demonstrates the development of urea nitrate as an effective and efficient catalyst for the synthesis of some 2-substituted benzothiazoles. Instant progress of reaction at room temperature under solvent-free condition, very high catalytic activity, inexpensive, clean reaction profile, operational simplicity, large-scale synthesis and appreciable yields are the main advantages of this protocol. These synthesized benzothiazoles have been evaluated for their antibacterial and antifungal activities against Gram-positive bacterium (Bacillus subtilis MTCC 121); two Gram-negative bacteria (Escherichia coli MTCC 1652 and Pseudomonas aeruginosa MTCC 741) and two fungi (Candida albicans MTCC 3017 and Saccharomyces cerevisiae MTCC 170). Compound 3n was found the most active against all the tested microbes.

Acylperoxycoumarins as ortho-C?H Acylating Agent via a Palladium(II)-Catalyzed Redox-Neutral Process

An unprecedented palladium(II)-catalyzed biomimetic aliphatic acyl (-COR) group transfer was observed from acyl-α-peroxycoumarins to the ortho C?H sites of directing arenes. Here, the C?H activation is associated with a concomitant acyl group transfer via a Pd(II)-catalyzed, redox-neutral process. While methods for ortho aroylation (-COAr) are well documented ortho acylation (-COR) processes are scarce, hence the present redox-neutral method is most ideal for o-acylation of directing substrates. (Figure presented.) .

Iron-catalyzed cyclization of aminothiols: An easy access to benzothiazoles and evaluation of their antimicrobial and anti-biofilm activities

Iron-catalyzed cyclization of aminothiol with various aromatic and heteroaromatic aldehydes produces a variety of benzothiazoles in moderate to excellent yield. Compound 3o with one carbazole functional moiety bridged between two benzothiazole scaffolds i

Mechanistic Insights into Pincer-Ligated Palladium-Catalyzed Arylation of Azoles with Aryl Iodides: Evidence of a PdII-PdIV-PdII Pathway

Pincer-based (R2POCNR′2)PdCl complexes along with CuI cocatalyst catalyze the arylation of azoles with aryl iodides to give the 2-arylated azole products. Herein, we report an extensive mechanistic investigation for the direct arylation of azoles involving a well-defined and highly efficient (iPr2POCNEt2)PdCl (2a) catalyst, which emphasizes a rare PdII-PdIV-PdII redox catalytic pathway. Kinetic studies and deuterium labeling experiments indicate that the C-H bond cleavage on azoles occurs via two distinct routes in a reversible manner. Controlled reactivity of the catalyst 2a underlines the iodo derivative (iPr2POCNEt2)PdI (3a) to be the resting state of the catalyst. The intermediate species (iPr2POCNEt2)Pd-benzothiazolyl (4a) has been isolated and structurally characterized. A determination of reaction rates of compound 4a with electronically different aryl iodides has revealed the kinetic significance of the oxidative addition of the C(sp2)-X electrophile, aryl iodide, to complex 4a. Furthermore, the reactivity behavior of 4a suggests that the arylation of benzothiazole proceeds via an oxidative addition/reductive elimination pathway involving a (iPr2POCNEt2)PdIV(benzothiazolyl)(Ar)I species, which is strongly supported by DFT calculations.

Efficient binary white light-emitting polymers grafted with iridium complexes as side groups

Efficient binary white-light-emitting electrophosphorescent copolymers were designed and synthesized via Suzuki polymerization. These copolymers were constructed by grafting a small amount of fluorinated iridium complexes as the side chain of the poly(flu

One-pot tandem approach for the synthesis of benzimidazoles and benzothiazoles from alcohols

Propylphosphonic anhydride (T3P) has been demonstrated to be an efficient and mild reagent for the one-pot synthesis of benzimidazoles and benzothiazoles from variety of alcohols. Mild conditions, short reaction time, broad functional group tolerance, low epimerization, easy and quick isolation of the products, excellent chemo selectivity, and excellent yields are main advantages of this procedure. Thus, the present method is utilizing alcohols instead of aldehydes.

Color tunable phosphorescent light-emitting diodes based on iridium complexes with substituted 2-phenylbenzothiozoles as the cyclometalated ligands

Several iridium complexes {iridium(III)bis[2-(3-methoxyphenyl)-1,3- benzothiozolato-N,C2′] acetylacetonate (MeO-BT) 2Ir(acac), iridium(III)bis[2-(2,4-difluorophenyl)-1,3- benzothiozolato-N,C2′] acetylacetonate (2F-BT) 2Ir(acac), and iridium(III)bis[2-(2,4-difluorophenyl)-6-fluoro-1,3- benzothiozolato-N,C2′] acetylacetonate (3F-BT) 2Ir(acac)} having different substituents on 2-phenylbenzothiazole have been synthesized. Several iridium complexes {iridium(III)bis[2-(3- methoxyphenyl)-1,3-benzothiozolato-N,C2′] acetylacetonate (MeO-BT)2Ir(acac), iridium(III)bis[2-(2,4-difluorophenyl)-1,3- benzothiozolato-N,C2′] acetylacetonate (2F-BT) 2Ir(acac), and iridium(III)bis[2-(2,4-difluorophenyl)-6-fluoro-1,3- benzothiozolato-N,C2′] acetylacetonate (3F-BT) 2Ir(acac)} having different substituents on 2-phenylbenzothiazole have been synthesized. The phosphorescent light emitting diodes (PHOLEDs) using these iridium complexes as dopant emitters were fabricated. The experimental results revealed that the emissive colors of PHOLEDs could be finely tuned by suitable modification of the substituents on the 2-phenylbenzothiazole ligands. Furthermore, these iridium complexes show better emissive properties than the known iridium(III)bis(2-phenylbenzothiozolato-N,C2′) acetylacetonate (BT)2Ir(acac).