837392-54-8Relevant articles and documents
4-aminopyrazolo [3, 4-d] pyrimidine derivative and application thereof
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Paragraph 0102; 0108-0114, (2021/08/19)
The invention discloses a 4-aminopyrazolo [3, 4-d] pyrimidine derivative and application thereof, the structure of the derivative is as shown in formula I, A is an aromatic ring group or an aromatic heterocyclic group; L is fat alkane; Cyclic is of an N-containing heterocyclic structure; Q is carbonyl or sulfonyl; R is alkane, aryl or heteroaryl. A novel 4-aminopyrazolo [3, 4-d] pyrimidine derivative is synthesized and screened, the activity of an ALK5 receptor can be inhibited in a dose-dependent mode, and the derivative or a solvate and a medicinal salt of the derivative can be applied to preparation of drugs for treating and/or preventing cancers.
HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK
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Page/Page column 28, (2012/09/11)
Disclosed herein are new heterocyclic compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibiting PAS Kinase (PASK) activity in a human or animal subject are also provided for the treatment of diseases such as diabetes mellitus.
Thienopyridine and furopyridine kinase inhibitors
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, (2008/06/13)
Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.