837430-14-5

Basic information

• Product Name: 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine
• Synonyms: 5,6,7,8-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE;5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine;1,2,4-Triazolo[4,3-a]pyrazine, 5,6,7,8-tetrahydro-, hydrochloride;5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride;5,6,7,8-Tetrahydro[1,2,4]triazolo[4,3-a]pyrazine monohydrochloride;_x005f\r5，6，7，8-Tetrahydro-1，2，4-triazolo[4，3-a]pyrazine Hydrochloride
• CAS NO: 837430-14-5
• Molecular Formula: C5H9ClN4
• Molecular Weight: 124.14
• Mol File: 837430-14-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 319.763 °C at 760 mmHg
• Flash Point: 147.187 °C
• Appearance: /
• Density: 1.539g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine(837430-14-5)
• EPA Substance Registry System: 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine(837430-14-5)

Safety Data

• RIDADR: UN2811
• Hazardous Substances Data: 837430-14-5(Hazardous Substances Data)

Usage

General Description

5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine, also known as TTP, is a polycyclic organic compound made of fused pyrazine and triazole rings. As an aromatic compound, it is characterized by the presence of several carbon and nitrogen atoms that form rings with alternating single and double bonds. While not extensively studied, it is recognized in the discipline of organic chemistry due to its unique structure. 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine often acts as an intermediate in the synthesis of other organic molecules. The specific properties, including toxicity and potential applications of this compound, are not widely documented in the current body of scientific literature. It is primarily of interest in academic and research settings, particularly in the field of organic synthesis.

Upstream product

• 68774-77-6 8-chloro-[1,2,4]triazolo[4,3-a]pyrazine 

Relevant articles and documents

(2R)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a] pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: A potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

A novel series of β-amino amides incorporating fused heterocycles, i.e., triazolopiperazines, were synthesized and evaluated as inhibitors of dipeptidyl peptidase IV (DPP-IV) for the treatment of type 2 diabetes. (2R)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H) -yl]-1-(2,4,5-trifluorophenyl)butan-2-amine (1) is a potent, orally active DPP-IV inhibitor (IC50 = 18 nM) with excellent selectivity over other proline-selective peptidases, oral bioavailability in preclinical species, and in vivo efficacy in animal models. MK-0431, the phosphate salt of compound 1, was selected for development as a potential new treatment for type 2 diabetes.