83747-21-1

Basic information

• Product Name: 3-(1,1,3-TRIOXO-1,3-DIHYDRO-1LAMBDA6-BENZO[D]ISOTHIAZOL-2-YL)-PROPIONIC ACID
• Synonyms: TIMTEC-BB SBB011991;3-(1,1,3-TRIOXO-1,3-DIHYDRO-1-BENZO[ D ]ISOTHIAZOL-2-YL)-PROPIONIC ACID;3-(1,1,3-TRIOXO-1,3-DIHYDRO-1LAMBDA6-BENZO[D]ISOTHIAZOL-2-YL)-PROPIONIC ACID;3-(1,1,3-TRIOXO-1,3-DIHYDROBENZO[D]ISOTHIAZOL-2-YL)-PROPIONIC ACID;1,2-benzisothiazole-2(3H)-propanoic acid, 3-oxo-, 1,1-diox;3-(1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)propanoic acid(SALTDATA: FREE);3-(1,1-dioxido-3-oxobenzo[d]isothiazol-2(3H)-yl)propanoic acid
• CAS NO: 83747-21-1
• Molecular Formula: C10H9NO5S
• Molecular Weight: 255.25
• Mol File: 83747-21-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 164-165 °C(Solv: methanol (67-56-1); ethyl ether (60-29-7))
• Boiling Point: 518.2°C at 760 mmHg
• Flash Point: 267.2°C
• Appearance: /
• Density: 1.581g/cm³
• Vapor Pressure: 1.46E-11mmHg at 25°C
• Refractive Index: 1.633
• PKA: 4.30±0.10(Predicted)
• CAS DataBase Reference: 3-(1,1,3-TRIOXO-1,3-DIHYDRO-1LAMBDA6-BENZO[D]ISOTHIAZOL-2-YL)-PROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1,1,3-TRIOXO-1,3-DIHYDRO-1LAMBDA6-BENZO[D]ISOTHIAZOL-2-YL)-PROPIONIC ACID(83747-21-1)
• EPA Substance Registry System: 3-(1,1,3-TRIOXO-1,3-DIHYDRO-1LAMBDA6-BENZO[D]ISOTHIAZOL-2-YL)-PROPIONIC ACID(83747-21-1)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 83747-21-1(Hazardous Substances Data)

Usage

General Description

3-(1,1,3-trioxo-1,3-dihydro-1lambda6-benzo[d]isothiazol-2-yl)-propionic acid is a chemical compound with potential pharmaceutical applications. It consists of a propionic acid derivative attached to a benzo[d]isothiazol-2-yl group. 3-(1,1,3-TRIOXO-1,3-DIHYDRO-1LAMBDA6-BENZO[D]ISOTHIAZOL-2-YL)-PROPIONIC ACID has been studied for its potential antimicrobial and anti-inflammatory properties, and it may have potential applications in the development of new drugs for treating various diseases. However, further research is needed to fully understand its biological activities and potential therapeutic uses.

InChI:InChI=1/C10H9NO5S/c12-9(13)5-6-11-10(14)7-3-1-2-4-8(7)17(11,15)16/h1-4H,5-6H2,(H,12,13)

Upstream product

• 107-94-8 chloropropionic acid 
• 81-07-2 saccharin 
• 128-44-9 saccharin sodium salt 
• 83747-24-4 2-(2'-Ethoxycarbonylethyl)-saccharin 
• 590-92-1 3-Bromopropionic acid 

Relevant articles and documents

Structural investigation on thiazolo[5,4-d]pyrimidines to obtain dual-acting blockers of CD73 and adenosine A2A receptor as potential antitumor agents

Adenosine pathway, including its generating enzyme (CD73) and its receptors represents a key target for cancer immunotherapy. Here we aimed to search for novel compounds able to co-target the CD73 and the A2A adenosine receptor (A2A

Acid derivatives of benzisothiazole-1,1-dioxide as inhibitors of rat lens aldose reductase

A number of 6-substituted 1,2-benzisothiazole-1,1-dioxide alkanoic acids were synthesized and evaluated for crude rat lens aldose reductase inhibitory activity. The inhibitory potency of the acetic (6a, 10a), propionic (6b, 10b, 11b), and isopropionic (6c, 16c, 11c) derivatives was very similar and generally lower than that of the reference compound, Sorbinil. The presence of an acyl moiety on the amino group in position 6, as in the acetic and propionic derivatives 14a-f and 15a,b, respectively, resulted in a significant increase in activity. A good potency was shown by compounds 14g and 15g, in which a second carboxylic function is present on the 6-acylamino group. Also the open products 16, which contain the phenylsulfonyl fragment found in several known inhibitors of aldose reductase, were obtained and tested in the rat lens assay.

Hypolipidemic activity of phthalimide derivatives. 3. A comparison of phthalimide and 1,2-benzisothiazolin-3-one 1,1-dioxide derivatives to phthalimidine and 1,2-benzisothiazoline 1,1-dioxide congeners

Previously it has been observed that N-substituted phthalimide derivatives with chain lengths of four carbon or oxygen atoms showed potent hypolipidemic activity in rodents at 20 (mg/kg)/day ip. The 1,2-benzisothiazolin-3-one 1,1-dioxide (saccharin) nucleus, itself, had also been observed to be active at the same dose. An investigation was undertaken to examine a series of 1,2-benzisothiazolin-3-one 1,1-dioxide analogues for their hypolipidemic activity in mice and to compare them to their respective phthalimide congeners. In addition, a series of 1,2-benzisothiazoline 1,1-dioxide and phthalimidine analogues was prepared, and their hypolipidemic activity was compared to the phthalimide analogues. These studies show that the respective congeners of 1,2-benzisothiazolin-3-one 1,1-dioxide compared favorably to phthalimide congeners in reducing serum triglyceride and cholesterol levels in male CF1 mice at 20 (mg/kg)/day ip. Of the saccharin derivatives, 3-oxo-1,2-benzisothiazoline-2-propionic acid 1,1-dioxide was the most effective in lowering serum cholesterol levels by 53% after 16 days dosing and 3-oxo-1,2-dibenzothiazoline-2-valeric acid 1,1-dioxide lowered serum triglycerides 56% after 14 days dosing. The 1,2-benzisothiazoline 1,1-dioxide and phthalimidine compounds were less active as hypolipidemic agents than their 1,2-benzisothiazolin-3-one 1,1-dioxide and phthalimide analogues, respectively.