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2(1H)-Pyrimidinone, 5-(trifluoromethyl)(9CI) is an organic compound characterized by the chemical formula C5H3F3N2O. It is a pyrimidinone derivative featuring a trifluoromethyl group at the 5-position. 2(1H)-Pyrimidinone, 5-(trifluoromethyl)(9CI) is recognized for its potential pharmacological activities, including antiviral, anticancer, and antimicrobial properties. The presence of the trifluoromethyl group enhances its utility in medicinal chemistry, making it a valuable building block for the synthesis of pharmaceuticals and agrochemicals. Furthermore, it serves as a research tool in biological studies and drug discovery initiatives.

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  • 83767-80-0 Structure
  • Basic information

    1. Product Name: 2(1H)-Pyrimidinone, 5-(trifluoromethyl)- (9CI)
    2. Synonyms: 2(1H)-Pyrimidinone, 5-(trifluoromethyl)- (9CI);2-Hydroxy-5-(trifluoromethyl)pyrimidine;5-(TrifluoroMethyl)-2-pyriMidinone;5-(trifluoromethyl)pyrimidin-2(1H)-one;5-(TRIFLUOROMETHYL)PYRIMIDIN-2-OL
    3. CAS NO:83767-80-0
    4. Molecular Formula: C5H3F3N2O
    5. Molecular Weight: 164.0853296
    6. EINECS: N/A
    7. Product Categories: PYRIMIDINE
    8. Mol File: 83767-80-0.mol
    9. Article Data: 1
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. CAS DataBase Reference: 2(1H)-Pyrimidinone, 5-(trifluoromethyl)- (9CI)(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2(1H)-Pyrimidinone, 5-(trifluoromethyl)- (9CI)(83767-80-0)
    11. EPA Substance Registry System: 2(1H)-Pyrimidinone, 5-(trifluoromethyl)- (9CI)(83767-80-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 83767-80-0(Hazardous Substances Data)

83767-80-0 Usage

Uses

Used in Pharmaceutical Industry:
2(1H)-Pyrimidinone, 5-(trifluoromethyl)(9CI) is utilized as a key building block in the synthesis of various pharmaceuticals due to its potential pharmacological activities. Its antiviral, anticancer, and antimicrobial properties make it a promising candidate for the development of new therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical sector, 2(1H)-Pyrimidinone, 5-(trifluoromethyl)(9CI) serves as a fundamental component in the creation of agrochemicals, leveraging its bioactive properties to combat pests and diseases in agriculture.
Used in Medicinal Chemistry Research:
2(1H)-Pyrimidinone, 5-(trifluoromethyl)(9CI) is employed as a research tool in medicinal chemistry. Its trifluoromethyl group allows for the exploration of structure-activity relationships and the enhancement of bioactive compounds' properties, contributing to the advancement of drug discovery.
Used in Biological Studies and Drug Discovery:
As a research tool, 2(1H)-Pyrimidinone, 5-(trifluoromethyl)(9CI) aids in biological studies and drug discovery efforts, providing insights into the mechanisms of action and potential applications of compounds with similar structures in various therapeutic areas.

Check Digit Verification of cas no

The CAS Registry Mumber 83767-80-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,3,7,6 and 7 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 83767-80:
(7*8)+(6*3)+(5*7)+(4*6)+(3*7)+(2*8)+(1*0)=170
170 % 10 = 0
So 83767-80-0 is a valid CAS Registry Number.

83767-80-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-(trifluoromethyl)-1H-pyrimidin-2-one

1.2 Other means of identification

Product number -
Other names 2-HYDROXY-5-(TRIFLUOROMETHYL)PYRIMIDINE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:83767-80-0 SDS

83767-80-0Downstream Products

83767-80-0Relevant articles and documents

Synthesis of Some 5-Trifluoromethylpyrimidines

Benneche, Tore,Undheim, Kjell

, p. 505 - 508 (2007/10/02)

5-Trifluoromethyl-2-pyrimidinones have been prepared by selective substitution reactions from 2-chloro-5-methylpyrimidine.

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