83767-82-2Relevant academic research and scientific papers
A Convenient Synthetic Route to N-Aryl and N-Alkylamino(alkyl) Phosphonates and Phosphine Oxides
Couture, A.,Deniau, E.,Woisel, P.,Grandclaudon, P.
, p. 2483 - 2486 (2007/10/02)
A variety of phosphorylated N-aryl and N-alkyl N-formyl and N-tert-butoxycarbonylaminomethyl derivatives have been efficiently prepared by treatment of the corresponding chloromethyl derivatives with a trialkyl phosphite or an alkyl diphenylphosphinite.These bifunctional compounds may be deprotonated with LDA and further submitted to electrophilic substitution.An acidic treatment of the resulting compounds gives rise to a range of N-aryl and N-alkylamino(alkyl) phosphonates and phosphine oxides.
Pyrimidinones as reversible metaphase arresting agents
Benneche, T,Strande, P,Oftebro, R,Undheim, K
, p. 463 - 472 (2007/10/02)
5-Halo-N(1)-substituted 2(1H)-pyrimidinones have the ability to cause reversible arrest of mitosis during metaphase.Highly active compounds have a heteroatom (O, S or N) in the β-position of the N(1)-carbon chain which is further substituted by an aryl gr
Substituted pyrimidin-2-ones and the salts thereof
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, (2008/06/13)
Compounds of the general formula: STR1 (wherein X represents a halogen atom or a trifluoromethyl group; R1 and R2 independently represent a hydrogen atom or a lower alkyl group; Z is --O--, --S--, --SO--, --SO2 -- or the group --NR4 -- wherein R4 is as defined for R hereinafter or represents the group COR5 in which R5 represents a hydrogen atom or an optionally substituted aryl, heterocyclic, aralkyl, lower alkyl or lower alkoxy group; R represents a C6-10 carbocyclic aromatic group or a heterocyclic group containing a 5-9 membered unsaturated or aromatic heterocyclic ring which ring contains one or more heteroatoms selected from O, N and S and optionally carries a fused ring which carbocyclic or heterocyclic group may carry one or more C1-4 alkyl or phenyl groups, said groups being optionally substituted; or, where Z represents the group >NR4, the group --ZR may represent a heterocyclic ring optionally carrying a fused ring and/or optionally substituted as defined for R; and R3 represents a hydrogen atom or a lower alkyl, lower alkenyl, lower alkynyl, lower alkanoyl, lower alkenoyl, C7-16 aralkyl or C6-10 arly group or a 5-9 membered unsaturated or aromatic heterocyclic ring); and, where acid or basic groups are present, the salts thereof; are useful in combating abnormal cell proliferation. The compounds of the invention are prepared by inter alia alkylation, ring closure and oxidation.
