83768-42-7

Basic information

• Product Name: 1-(N-Acetyl-N-phenylamino)methyl-5-chloropyrimidin-2-one
• Synonyms: 1-(N-Acetyl-N-phenylamino)methyl-5-chloropyrimidin-2-one
• CAS NO: 83768-42-7
• Molecular Weight: 277.71
• Mol File: 83768-42-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(N-Acetyl-N-phenylamino)methyl-5-chloropyrimidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(N-Acetyl-N-phenylamino)methyl-5-chloropyrimidin-2-one(83768-42-7)
• EPA Substance Registry System: 1-(N-Acetyl-N-phenylamino)methyl-5-chloropyrimidin-2-one(83768-42-7)

Safety Data

• Hazardous Substances Data: 83768-42-7(Hazardous Substances Data)

Upstream product

• 42748-90-3 5-chloro-2(1H)-PYRIMIDONE hydrochloride 
• 83767-89-9 N-(chloromethyl)-N-phenylacetamide 

Relevant articles and documents

Substituted pyrimidin-2-ones and the salts thereof

Compounds of the general formula: STR1 (wherein X represents a halogen atom or a trifluoromethyl group; R1 and R2 independently represent a hydrogen atom or a lower alkyl group; Z is --O--, --S--, --SO--, --SO2 -- or the group --NR4 -- wherein R4 is as defined for R hereinafter or represents the group COR5 in which R5 represents a hydrogen atom or an optionally substituted aryl, heterocyclic, aralkyl, lower alkyl or lower alkoxy group; R represents a C6-10 carbocyclic aromatic group or a heterocyclic group containing a 5-9 membered unsaturated or aromatic heterocyclic ring which ring contains one or more heteroatoms selected from O, N and S and optionally carries a fused ring which carbocyclic or heterocyclic group may carry one or more C1-4 alkyl or phenyl groups, said groups being optionally substituted; or, where Z represents the group >NR4, the group --ZR may represent a heterocyclic ring optionally carrying a fused ring and/or optionally substituted as defined for R; and R3 represents a hydrogen atom or a lower alkyl, lower alkenyl, lower alkynyl, lower alkanoyl, lower alkenoyl, C7-16 aralkyl or C6-10 arly group or a 5-9 membered unsaturated or aromatic heterocyclic ring); and, where acid or basic groups are present, the salts thereof; are useful in combating abnormal cell proliferation. The compounds of the invention are prepared by inter alia alkylation, ring closure and oxidation.