83769-59-9Relevant academic research and scientific papers
An annulative transfer hydrogenation strategy enables straightforward access to tetrahydro fused-pyrazine derivatives
Xiong, Biao,Zhang, Shu-Di,Chen, Lu,Li, Bin,Jiang, Huan-Feng,Zhang, Min
supporting information, p. 10636 - 10639 (2016/09/02)
A ruthenium-catalysed annulative transfer hydrogenation strategy, enabling straightforward access to tetrahydro fused-pyrazine derivatives from N-heteroaryl diamines and vicinal diols, has been demonstrated for the first time. Such a synthesis proceeds with unprecedented synthetic effectiveness including high step- and atom efficiency, generation of water as the sole by-product, short reaction time and no need for external high pressure H2 gas, offering an important basis for the transformation of vicinal diols, a class of bio-mass derived resources, into functionalized products.
Regioselectivite de l'hydrogenation catalitique de quelques pyridopyrazines
Cosmao, Jean-Marie,Collignon, Noel,Queguiner, Guy
, p. 2785 - 2791 (2007/10/02)
Catalytic hydrogenation on palladium-carbon in ethanol of several pyridopyrazines leads to mixtures of the 1,2,3,4- and 5,6,7,8-tetrahydro derivatives except in two cases: the reduction of the nonsubstituted heterocycle takes place on the pyrazine
