83783-49-7

Basic information

• Product Name: 1-(2,4-dichlorophenyl)cyclopropanecarbonyl chloride
• Synonyms: 1-(2,4-dichlorophenyl)cyclopropanecarbonyl chloride;1-(2,4-Dichlorophenyl)-1-cyclopropanecarboxylic acid chloride;Einecs 280-783-5
• CAS NO: 83783-49-7
• Molecular Formula: C₁₀H₇Cl₃O
• Molecular Weight: 249.52098
• EINECS: 280-783-5
• Mol File: 83783-49-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 313.5°C at 760 mmHg
• Flash Point: 131.7°C
• Appearance: /
• Density: 1.504g/cm³
• Vapor Pressure: 0.000496mmHg at 25°C
• Refractive Index: 1.608
• CAS DataBase Reference: 1-(2,4-dichlorophenyl)cyclopropanecarbonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,4-dichlorophenyl)cyclopropanecarbonyl chloride(83783-49-7)
• EPA Substance Registry System: 1-(2,4-dichlorophenyl)cyclopropanecarbonyl chloride(83783-49-7)

Safety Data

• Hazardous Substances Data: 83783-49-7(Hazardous Substances Data)

Usage

General Description

1-(2,4-dichlorophenyl)cyclopropanecarbonyl chloride is a chemical compound with the molecular formula C10H7Cl2O. It is a derivative of cyclopropane and is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 1-(2,4-dichlorophenyl)cyclopropanecarbonyl chloride is a reactive and highly toxic substance that can cause severe skin and eye irritation upon contact. It is also a powerful irritant to the respiratory system when inhaled. Therefore, proper safety precautions, such as wearing protective clothing and handling it in a well-ventilated area, should be followed when working with this chemical. Additionally, it should be stored in a cool, dry place away from heat and open flames to prevent the risk of fire or explosion.

InChI:InChI=1/C10H7Cl3O/c11-6-1-2-7(8(12)5-6)10(3-4-10)9(13)14/h1-2,5H,3-4H2

Downstream Products

• 1072810-08-2 C₁₁H₁₁Cl₂NO₂ 

Relevant articles and documents

Design, synthesis, and analysis of antagonists of GPR55: Piperidine-substituted 1,3,4-oxadiazol-2-ones

A series of 1,3,4-oxadiazol-2-ones was synthesized and tested for activity as antagonists at GPR55 in cellular beta-arrestin redistribution assays. The synthesis was designed to be modular in nature so that a sufficient number of analogues could be rapidly accessed to explore initial structure–activity relationships. The design of analogues was guided by the docking of potential compounds into a model of the inactive form of GPR55. The results of the assays were used to learn more about the binding pocket of GPR55. With this oxadiazolone scaffold, it was determined that modification of the aryl group adjacent to the oxadiazolone ring was often detrimental and that the distal cyclopropane was beneficial for activity. These results will guide further exploration of this receptor.

Synthesis of β-, γ-, and δ-lactams via Pd(II)-catalyzed C-H activation reactions

Pd(II)-catalyzed intramolecular amination of sp2 and sp3 C-H bonds are developed using a combination of CuCl2 and AgOAc as the oxidant. The reaction protocol tolerates the presence of a double bond in the substrates. This catalytic reaction provides practical access to a wide range of β-, γ-, and δ-lactams. Copyright