83818-45-5Relevant academic research and scientific papers
Copper-catalyzed aldol-type addition of ketones to aromatic nitriles: A simple approach to enaminone synthesis
Yu, Xiaoqiang,Wang, Longxiang,Feng, Xiujuan,Bao, Ming,Yamamoto, Yoshinori
supporting information, p. 2885 - 2887 (2013/04/24)
An efficient method for the synthesis of enaminones is described. The aldol-type addition of ketones to aromatic nitriles proceeded smoothly in the presence of a simple copper catalyst system (CuI-2,2′-bipyridine-NaO tBu) in N,N-dimethylformamide. Enaminones in satisfactory to excellent yields were produced using this technique. The Royal Society of Chemistry 2013.
