83821-46-9Relevant academic research and scientific papers
Synthesis and anti-HBV activities evaluation of new ethyl 8-imidazolylmethyl-7-hydroxyquinoline-3-carboxylate derivatives in vitro
Liu, Yajing,Zhao, Yanfang,Zhai, Xin,Liu, Xiuping,Sun, Lixue,Ren, Yanxia,Gong, Ping
scheme or table, p. 446 - 452 (2009/04/11)
Some new ethyl 8-imidazolylmethyl-7-hydroxyquinoline-3-carboxylate derivatives have been synthesized and evaluated for their anti-hepatitis B virus (HBV) activities and cytotoxicities in HepG2.2.15 cells stable transfection with HBV. Compounds 13a, 11b, 11c, 12c, 13c, 11g, and 12g inhibited the expression of the viral antigens HBsAg or HBeAg in a low concentration, of which 11c (IC50 = 12.6 μM, SI = 12.4), 12c (IC50 = 3.5 μM, SI = 37.9), and 12g (IC50 = 2.6 μM, SI = 61.6) showed more active abilities to inhibit the replication of HBV DNA than the positive control lamivudine (3TC, IC50 = 343.2 μM, SI = 7.0).
The Synthesis of the Monomethyl Isomers of Benzonaphththiophene
Tominaga, Yoshinori,Pratap, Ram,Castle, Raymond N.,Lee, Milton L.
, p. 859 - 863 (2007/10/02)
All isomers of the monomethylbenzonaphththiophenes were synthesized using photocyclization of 3-styrylbenzothiophenes.The 1-, 3-, 4-, and 5-methylbenzonaphthothiophenes were synthesized by irradiation of the corresponding methylated
