83823-56-7

Usage

Uses

Used in Pharmaceutical Industry:
6,8-Dichloro-2H-chromene-3-carbonitrile is utilized as an intermediate in the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
6,8-DICHLORO-2H-CHROMENE-3-CARBONITRILE also serves as an intermediate in the production of agrochemicals, playing a crucial role in the creation of pesticides and other agricultural products designed to protect crops and enhance agricultural yields.
Used in Antimicrobial Applications:
6,8-Dichloro-2H-chromene-3-carbonitrile has been investigated for its antimicrobial properties, making it a potential candidate for use in products that combat bacterial infections and promote public health.
Used in Anti-Fungal Applications:
6,8-DICHLORO-2H-CHROMENE-3-CARBONITRILE's antifungal potential has been explored, suggesting its use in formulations that prevent fungal growth, which is particularly important in medical and agricultural settings.
Used as a Herbicide:
6,8-Dichloro-2H-chromene-3-carbonitrile has been studied for its potential as a herbicide, indicating its use in controlling and eliminating unwanted plant species, thereby supporting effective and efficient agricultural practices.
Used as an Insecticide:
6,8-DICHLORO-2H-CHROMENE-3-CARBONITRILE's insecticidal properties are under investigation, which could lead to its application in controlling and reducing insect populations that are detrimental to crops and the environment.

Upstream product

• 107-13-1 acrylonitrile 
• 90-60-8 3,5-dichlorosalicyclaldehyde 

Downstream Products

• 83823-07-8 6,8-Dichloro-2H-chromene-3-carboxylic acid 
• 83823-28-3 (6,8-Dichloro-2H-chromen-3-yl)-(2-imino-2H-pyridin-1-yl)-methanone 

Relevant academic research and scientific papers

Microwave-Assisted Rapid and Efficient Synthesis of New Series of Chromene-Based 1,2,4-Oxadiazole Derivatives and Evaluation of Antibacterial Activity with Molecular Docking Investigation

A new series of novel chromene-based oxadiazole derivatives were synthesized from a variety of chromene-based amidoximes with readily available carboxylic acids under conventional oil bath heating as well as under microwave irradiation. The use of commercially available EDCI and HOBt as coupling reagents in DMF combined with microwave heating resulted in high yields and purities of the product 1,2,4-oxadiazoles in an expeditious manner. This methodology is successfully applied to synthesize 18 numbers of new 2H-chromene-substituted 1,2,4-oxadiazole derivatives in good to high yields. The structure of the product was ascertained by X-ray crystallographic analysis. All the synthesized compounds were evaluated for their in vitro antibacterial activity against two different pathogenic bacterial strains, that is, Escherichia coli (MTCC614) and Klebsiella pneumoniae (MTCC4031). The obtained results from in vitro antimicrobial assays indicated that 6g and 6h exhibited good antibacterial activity nearer to the standard drug, gentamicin. The molecular docking studies showed that compounds 6g and 6h show hydrogen bonding interaction with the bacterial target DNA gyrase of E.?coli.

One pot, three component 1,3 dipolar cycloaddition: Regio and diastereoselective synthesis of spiropyrrolidinyl indenoquinoxaline derivatives

A competent and highly discriminating one-pot synthesis of highly diversified novel functionalized indenoquinoxalone grafted spiropyrrolidine linked chromene-3-carbonitrile conjugates accumulating three pharmocophoric cores, heterocyclic indenoquinoxalone, pyrrolidines and chromene-3-carbonitrile in a single molecular framework by means of 1,3-dipolar cycloaddition reaction between indenoquinoxalone, proline/benzyl amine and chromene-3-carbonitrile in ethanol under classical and microwave conditions is described. The three component 1,3-dipolar cycloaddition reaction proceeds via in situ generation of azomethine ylides by the decarboxylative condensation of indenoquinoxalone with proline/benzyl amine and their selectivity towards the endo cyclic double bonds of dipolarophile (chromene-3-carbonitrile) leading to the formation of highly functionalised regio- and diastereoselective molecular hybrids. This methodology exemplifies the green chemistry protocol such as mild reaction conditions, high yields, one-pot procedure and operational simplicity.

Chromene and Chroman 3-Carboxamides and Some Related Compounds as a New Class of Centrally Acting Agents

A number of chromene-3-carboxamides (7), 3-Aminochromans (11) and 3-aminomethylchromans (9) have been synthesized.Chromene-3-carboxamides have been found to exhibit strong central muscle relaxant activity compared to mephesin.