83845-20-9

Upstream product

• 613-90-1 benzoyl cyanide 
• 10255-95-5 2-phenylmalonamide 
• 3041-40-5 2-phenylmalononitrile 

Downstream Products

• 1381804-02-9 C₁₁H₈ClN₃O 
• 1381802-97-6 3-amino-4-chloro-5-oxo-2-phenyl-2,5-dihydro-1H-pyrrole-2-carbonitrile 
• 83845-09-4 4-Amino-8-phenylimidazo<1,5-a>-1,3,5-triazine 
• 83845-05-0 5-Amino-4-cyano-4-phenyl-4H-imidazole 
• 83845-27-6 α-Cyano-α-<(methoxymethylene)amino>phenylacetonitrile 
• 83845-23-2 α-Amino-α-cyanophenylacetonitrile p-toluenesulfonate 

Relevant academic research and scientific papers

Approaches to the construction of substituted 4-amino-1 H -pyrrol-2(5 H)-ones

Fully substituted 4-aminopyrrolones are easily accessed via simple routes starting from imines, ketones, or α-bromophenyl acetonitriles. Imines were reacted with KCN/NH4Cl in aqueous ethanol to produce α-arylamino benzyl cyanides. On the other hand, ketones were transformed to the desired α-amino nitriles using a modified Strecker reaction. Then, α-amino nitrile precursors were allowed to react with a suitable acyl halide to produce the corresponding amides. Further treatment of these amides with ethanolic KOH converted them to highly substituted 4-amino-1H-pyrrol-2(5H)- one derivatives in moderate to excellent yields.

Translocative Rearrangements. Generality of the Formamidine-Induced Rearrangement of 4-Substituted 5-Amino-4-cyano-4H-imidazoles

The generality of two different courses of cyclisation reactions for 4-substituted 5-amino-4-cyano-4H-imidazoles (5) is demonstrated.One results from treatment of 5 with formamidine in a "translocative rearrangement" that leads to 8-substituted 4-aminoimi