83860-26-8Relevant articles and documents
12-Carboxyretinoic Acids. Synthesis and Structure
Lewin, Anita H.,Whaley, M. Glenn,Parker, Steven R.,Carroll, F. Ivy
, p. 1799 - 1807 (2007/10/02)
Four isomeric 12-carboxyretinoic acids and their dimethyl esters (trans, 13-cis, 11-cis, and 11-cis,13-cis), along with two isomeric retinoic anhydrides (13-cis and 11-cis,13-cis), have been prepared and fully characterized.The primary product of the base-promoted condensation of trans-(β-ionylidene)acetaldehyde and β-methylglutaconate has been shown to be the 11-cis,13-cis-diacid.The interconversions and relative stabilities of these retinoids are discussed in terms of their conformations