83863-63-2

Usage

Uses

Used in Pharmaceutical Synthesis:
Dibenzofuran-2-sulfonic acid is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of novel drug molecules with potential therapeutic properties.
Used in Dye Production:
In the dye industry, Dibenzofuran-2-sulfonic acid is utilized as a building block for the creation of various dyes, capitalizing on its chemical structure to produce a spectrum of colorants for different applications.
Used in Wastewater Treatment:
Dibenzofuran-2-sulfonic acid is employed as a component in the treatment of wastewater, potentially aiding in the removal of pollutants and contributing to environmental remediation efforts.
Used as a Corrosion Inhibitor:
In industrial settings, DIBENZOFURAN-2-SULFONIC ACID serves as a corrosion inhibitor, protecting materials from the damaging effects of corrosive agents and extending the lifespan of equipment and structures.
Used in Analytical Chemistry as a pH Indicator:
Dibenzofuran-2-sulfonic acid is used as a pH indicator, leveraging its chemical properties to signal changes in acidity or alkalinity in various solutions.
Used in the Production of Fluorescent Dyes:
DIBENZOFURAN-2-SULFONIC ACID is also utilized in the creation of fluorescent dyes, where its unique properties allow for applications in fields such as bioimaging and diagnostics, where the visibility of specific markers or structures is crucial.

InChI:InChI=1/C12H8O4S/c13-17(14,15)8-5-6-12-10(7-8)9-3-1-2-4-11(9)16-12/h1-7H,(H,13,14,15)/p-1

Upstream product

• 132-64-9 dibenzofuran 

Downstream Products

• 23602-98-4 dibenzofuran-2-sulfonyl chloride 
• 147224-77-9 dibenzofuran-2-sulfonic acid anilide 
• 1623-92-3 4-phenoxyphenylsulfonyl chloride 
• 203640-01-1 (R)-2-(Dibenzofuran-2-sulfonylamino)-3-(1H-indol-3-yl)-propionic acid benzyl ester 

Relevant academic research and scientific papers

Synthesis and biological activity of various derivatives of a novel class of potent, selective, and orally active prostaglandin D2 receptor antagonists. 1. Bicyclo[2.2.1]heptane derivatives

Novel prostaglandin D2 (PGD2) receptor antagonists were synthesized as a potential new class of antiallergic agents having a bicyclo[2.2.1] heptane ring system with sulfonamide groups. Some of them exhibit extremely potent antagonism of the PGD2 receptor in radioligand binding and cAMP formation assays with IC50 values below 50 nM and much less antagonism of TXA2 and PGI2 receptors. These potent PGD2 receptor antagonists, when given orally, dramatically suppress various allergic inflammatory responses such as increased vascular permeability in allergic rhinitis, conjunctivitis, and asthma models. The excellent pharmacological profiles of PGD2 receptor antagonists, originally synthesized in our laboratories, are of potentially great clinical significance. This study also provides experimental evidence suggesting that PGD2 plays an important role in the pathogenesis of allergic diseases.

Highly selective and orally active inhibitors of type IV collagenase (MMP-9 and MMP-2): N-sulfonylamino acid derivatives

Various N-sulfonylamino acid derivatives were synthesized and evaluated for their in vitro and in vivo activities to inhibit type IV collagenase (MMP-9 and MMP-2). When the amino acid residue and the sulfonamide moiety were modified, their inhibitory activities were greatly affected by the structure of the sulfonamide moiety. A series of aryl sulfonamide derivatives containing biaryl, tetrazole, amide, and triple bond were found to be potent and highly selective inhibitors of MMP-9 and MMP-2. In addition, these compounds were orally active in animal models of tumor growth and metastasis. These results revealed the potential of the N-sulfonylamino acid derivatives as a new type of candidate drug for the treatment of cancer.