83864-81-7Relevant academic research and scientific papers
Synthesis and anti-platelet activity of obovatol derivatives
Kwak, Jae-Hwan,Lee, Seul,Park, Eun-Seok,In, Jin-Kyung,Song, Jiho,Kim, Young Jin,Choi, Nam Song,Lee, Heesoon,Yun, Yeo-Pyo,Hong, Jin Tae,Kwak, Young-Shin,Min, Kyung Hoon,Jung, Jae-Kyung
experimental part, p. 1107 - 1112 (2012/08/07)
Obovatol derivatives were synthesized and evaluated for anti-platelet activity. Three derivatives (1, 2, 4i) displayed equipotent activity to obovatol in arachidonic acid-induced platelet aggregation. An initial SAR study revealed that the introduction of alkoxy group in B ring could enhance inhibitory activity.
Novel obovatol derivatives or pharmaceutically acceptable salts thereof, preparation method thereof and pharmaceutical composition for the prevention and treatment of cancer containing the same as an active ingredient
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Page/Page column 5, (2009/10/01)
Disclosed herein are novel obovatol derivatives represented by Chemical Formula 1, and pharmaceutically acceptable salts thereof. Having the ability to inhibit the growth of cancer cells and induce apoptosis in cancer cells, the derivatives or pharmaceuti
