83864-99-7

Basic information

• Product Name: (2E)-3-(2,2-diphenyl-1,3-benzodioxol-5-yl)prop-2-enoic acid
• CAS NO: 83864-99-7
• Molecular Formula: C₂₂H₁₆O₄
• Molecular Weight: 344.36
• Mol File: 83864-99-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 528.4°C at 760 mmHg
• Flash Point: 188.9°C
• Density: 1.309g/cm³
• Vapor Pressure: 5.39E-12mmHg at 25°C
• Refractive Index: 1.673
• CAS DataBase Reference: (2E)-3-(2,2-diphenyl-1,3-benzodioxol-5-yl)prop-2-enoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-3-(2,2-diphenyl-1,3-benzodioxol-5-yl)prop-2-enoic acid(83864-99-7)
• EPA Substance Registry System: (2E)-3-(2,2-diphenyl-1,3-benzodioxol-5-yl)prop-2-enoic acid(83864-99-7)

Safety Data

• Hazardous Substances Data: 83864-99-7(Hazardous Substances Data)

Upstream product

• 73263-62-4 5-trans-caffeoylshikimic acid 
• 2051-90-3 Dichlorodiphenylmethane 
• 331-39-5 caffeic acid 

Relevant articles and documents

Synthesis and evaluation of new sesamol-based phenolic acid derivatives with hypolipidemic, antioxidant, and hepatoprotective effects

The objective of this study is to synthesize a series of sesamol-based phenolic acid derivatives, which were designed by combination principle. The hypolipidemic activity of all these compounds was preliminarily screened by acute hyperlipidemic mice model induced by Triton WR 1339, in which compound T6 exhibited more significant reducing plasma TG and TC than fenofibrate. Compound T6 was also found to obviously decrease TG and TC both in the plasma and hepatic tissue of high-fat-diet-induced hyperlipidemic mice. Moreover, T6 showed hepatoprotective effects, which remarkable amelioration in characteristic liver enzymes was examined and the histopathological observation displayed that compound T6 inhibited lipids accumulation in the hepatic. The levels of PPAR-α receptor related to lipids metabolism in hepatic tissue were upregulated after T6 treatment. Other potent effects of T6 such as antioxidant and anti-inflammatory activity were also observed. On the bases of these findings, compound T6 may serve as an effective hypolipidemic and hepatoprotective agent. [Figure not available: see fulltext.]

A one pot process for the preparation of caffeic acid ester derivatives

The present invention relates to a one pot process for the preparation of caffeic acid ester derivatives of the formula I: ???whereinAr is aryl, which is unsubstituted or substituted with halogen, hydroxy, C1-6 alkyl or C1-6 alkoxy,A is C1-6 alkylene, C2-6 alkenylene or C2-6 alkynylene,m is a number from 0 to 6; andB is C1-6 alkyl or aryl, which is unsubstituted or substituted with halogen, hydroxy, C1-6 alkyl or C1-6 alkoxy; ???which process comprises reacting, in a suitable solvent for esterification of a carboxylic acid derivative, a compound of the formula II: ???whereinAr and A are as defined above. ???with a halogenating reagent and alcohol of the formula III:H-(CH2)m-B ???whereinm and B are as defined above.