83881-09-8

Basic information

• Product Name: MoMetasone Furoate IMpurity D
• Synonyms: MoMetasone Furoate IMpurity D;21-Chloro-17α-[(2-furanylcarbonxyl)oxy]-9β,11β-oxido-16α-Methylpregna-1,4-diene-3,20-dione;Mometasone Furoate Epoxy Impurity;21-Chloro-17α-[(2-furanylcarbonxyl)oxy]-9β-oxido-16α-methylpregna-1,4-diene-3,20-dione Mometasone Furoate Impurity D;(4aS,4bS,5aS,6aS,7R,8R,9aS,9bS)-7-(2-chloroacetyl)-4a,6a,8-trimethyl-2-oxo-2,4a,5a,6,6a,7,8,9,9a,9b,10,11-dodecahydrocyclopenta[1,2]phenanthro[4,4a-b]oxiren-7-yl furan-2-carboxylate;Mometasone Furoate EP Impurity D
• CAS NO: 83881-09-8
• Molecular Formula: C₂₇H₂₉ClO₆
• Molecular Weight: 484.96856
• Product Categories: Pharmaceuticals, Intermediates & Fine Chemicals, Steroids
• Mol File: 83881-09-8.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)
• CAS DataBase Reference: MoMetasone Furoate IMpurity D(CAS DataBase Reference)
• NIST Chemistry Reference: MoMetasone Furoate IMpurity D(83881-09-8)
• EPA Substance Registry System: MoMetasone Furoate IMpurity D(83881-09-8)

Safety Data

• Hazardous Substances Data: 83881-09-8(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 83881-09-8 differently. You can refer to the following data:
1. A21-Chloro-17α-[(2-furanylcarbonxyl)oxy]-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione is a impurity of Mometasone Furoate.
2. A21-Chloro-17α-[(2-furanylcarbonxyl)oxy]-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione (Mometasone EP Impurity D) is a impurity of Mometasone Furoate.

Upstream product

• 527-69-5 2-furancarbonyl chloride 
• 83881-08-7 21-chloro-17α-hydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione 
• 24916-90-3 17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione 

Downstream Products

• 83919-23-7 Mometasone furoate 

Relevant articles and documents

An unusual rearrangement product formed during production of mometasone furoate (Sch 32088)

The structure of an unusual rearrangement product obtained during the production of mometasone furoate (Sch 32088) was assigned on the basis of NMR and X-ray crystallography data. - Keywords: mometasone furoate; rearrangement product; mechanism; NMR data; X-ray

Method for preparing mometasone furoate

The invention provides a method for preparing mometasone furoate avoiding introducing potential genotoxic impurities. According to the method, the condition is mild, and the molar yield of the whole route can be over 80 percent.

Unusual hydroxy-γ-sultone byproducts of steroid 21- methanesulfonylation. An efficient synthesis of mometasone 17-furoate (Sch 32088)

An efficient two stage synthesis of the steroid anti-inflammatory agent mometasone 17-furoate (Sch 32088) 4 from 17α,21-dihydroxy-16α-methyl- 9β,11β-oxidopregna-1,4-diene-3,20-dione 6 is described and the structures of unusual δ-hydroxy-γ-sultone byproducts of 4-dimethylaminopyridine catalyzed methanesulfonylation of 21-hydroxy-20-ketosteroids are deduced.