83881-37-2

Basic information

• Product Name: Cetirizine Amide
• Synonyms: 2-[2-[4-[(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-acetamide;Cetirizine Amide;UCB-L 172;2-[2-(4-[^a-(4-Chlorophenyl)benzyl]-1-piperazinyl)ethoxy]acetaMide, 97%;2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)-piperazin-1-yl)ethoxy)acetamide
• CAS NO: 83881-37-2
• Molecular Formula: C₂₁H₂₆ClN₃O₂
• Molecular Weight: 387.91
• Product Categories: Aromatics Compounds;Aromatics;Heterocycles;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 83881-37-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 539.3°C at 760 mmHg
• Flash Point: 280°C
• Appearance: /
• Density: 1.21g/cm³
• Vapor Pressure: 1.06E-11mmHg at 25°C
• Refractive Index: 1.588
• Storage Temp.: Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 15.56±0.40(Predicted)
• CAS DataBase Reference: Cetirizine Amide(CAS DataBase Reference)
• NIST Chemistry Reference: Cetirizine Amide(83881-37-2)
• EPA Substance Registry System: Cetirizine Amide(83881-37-2)

Safety Data

• Hazardous Substances Data: 83881-37-2(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

InChI:InChI=1/C21H26ClN3O2/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)25-12-10-24(11-13-25)14-15-27-16-20(23)26/h1-9,21H,10-16H2,(H2,23,26)

Upstream product

• 83881-52-1 cetirizine dihydrochloride 
• 36961-64-5 2-(2-chloroethoxy)acetamide 
• 303-26-4 N-(4-chlorobenzhydryl)piperazine 

Downstream Products

• 83881-52-1 cetirizine dihydrochloride 
• 909779-33-5 (R)-2-(2-{4-[(4-chlorophenyl)phenylmethyl]piperazin-1-yl}ethoxy)acetamide 
• 909779-47-1 (S)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide 
• 909779-48-2 (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide - (S)-pyrrolidone-5-carboxylic acid 
• 83881-51-0 cetirizine 

Relevant articles and documents

NOVEL WATER BASED PROCESS FOR THE PREPARATION OF SUBSTITUTED DIPHENYLMETHYL PIPERAZINES

The present invention relates to a novel water based process for the preparation of substituted diphenylmethyl piperazines of Formula I and pharmaceutically acceptable salts wherein X1 and X2 represent independently a hydrogen, a halogen, a straight or branched chain lower alkyl, alkoxy or a hydroxyl radical and R is selected from groups such as acyl, alkyl, alkenyl, aralalkyl, aralalkenyl aralkyl, and aralalkenyl or aralkenyl hydroxyalkyl, aryloxyalkyl, alkoxyalkyl, aminoalkyl or its derivative comprising, reacting a compound of Formula II, with a compound of formula R—X where R is as defined above and X is suitable leaving group which includes halides, but not limiting use of other leaving groups such as tosylate, mesylate and activated acid groups such as acyl halide, anhydrides, mixed anhydrides etc. using water as a solvent, in presence of a catalyst and a base, at 25-100° C.;

Enantiomers of 1-[(4-chlorophenyl)phenylmethyl]-4-[(4-methylphenyl) sulfonyl]piperazine

Levorotatory and dextrorotatory enantiomers of 1-[(4-chlorophenyl)phenylmethyl]-4-[(4-methylphenyl)sulfonyl]piperazine of the formula STR1 their preparation and use for the preparation of substantially optically pure enantiomers of 1-[(4-chlorophenyl)phenylmethyl]piperazine, which are themselves valuable intermediate products for the preparation of optically active therapeutic compounds having a very high degree of optical purity.