83881-46-3Relevant articles and documents
PROCESS FOR PREPARING OPTICALLY ACTIVE CETIRIZINE OR ITS SALT
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Page/Page column 8, (2008/06/13)
Provided are a process for preparing optically active cetirizine or its salt from racemic cetirizine or its salt using glutamate of 2-[2-[4-[(4-chlorphenyl)phenylmethyl]-1-piperazinyl] ethoxy]acetic ester and the glutamate of 2-[2-[4-[(4-chlorophenyl)phen
A large-scale synthesis of enantiomerically pure cetirizine dihydrochloride using preparative chiral HPLC
Pflum, Derek A.,Wilkinson, H. Scott,Tanoury, Gerald J.,Kessler, Donald W.,Kraus, Hali B.,Senanayake, Chris H.,Wald, Stephen A.
, p. 110 - 115 (2013/09/07)
Enantiomerically pure cetirizine can be prepared by preparative HPLC separation of cetirizine amide. The amide has an α value of 2.76 (USP resolution of 8.54) using a Chiralpak AD column, and 0.5 wt % of the amide (based on packing material) can be injected per run.
A process for the preparation of esters of [2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]-ethoxy]acetic acid
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, (2008/06/13)
The invention provides a process for the preparation of esters [2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetic acid, of the formula (I) wherein X represents a halogen atom and R represents a lower alkyl group comprising reacting: (a) a co