838845-69-5Relevant academic research and scientific papers
Dihydropyrido[2,3-d]pyrimidines as a new class of antileishmanial agents
Agarwal, Anu,Ramesh,Ashutosh,Goyal, Neena,Chauhan, Prem M.S.,Gupta, Suman
, p. 6678 - 6684 (2005)
A series of dihydropyrido[2,3-d]pyrimidines have been synthesized and screened for its in vitro antileishmanial activity profile in promastigote and amastigote models. Compounds 2a-2l have shown 83-100% inhibition against promastigotes and 79-100% inhibition against amastigotes at a concentration of 50 μg/mL.
Thiourea dioxide in water as a recyclable catalyst for the synthesis of structurally diverse dihydropyrido[2,3-d]pyrimidine-2,4-diones
Verma, Sanny,Jain, Suman L.
experimental part, p. 2595 - 2600 (2012/07/14)
A series of dihydropyrido[2,3-d]pyrimidine-2,4-diones derivatives were synthesized by the three-component reaction of 6-amino-1,3-dimethyl uracil, aromatic aldehydes, and 1,3-dicarbonyl compound catalyzed by thiourea dioxide in aqueous media. Importantly, the aqueous layer containing thiourea dioxide could be reused for several runs without significant loss in catalytic activity. This method provided several advantages such as inexpensive, recyclable catalyst, easier work-up, milder reaction conditions and environmental benign nature.
First report on the abnormal dearylation/alkylation reaction in one-pot hantzch synthesis with 6-amino-1,3-dimethyl uracil
Agarwal, Anu,Chauhan, Prem M. S.
, p. 4447 - 4461 (2007/10/03)
First report on the abnormal dearylation/dealkylation reaction occurring during dehydrogenation in one-pot, three-component condensation of dihydropyrido[2,3-d]pyrimidines.
