83894-65-9Relevant academic research and scientific papers
3′-[4-Aryl-(1,2,3-triazol-1-yl)]-3′-deoxythymidine analogues as potent and selective inhibitors of human mitochondrial thymidine kinase
Van Poecke, Sara,Negri, Ana,Gago, Federico,Van Daele, Ineke,Solaroli, Nicola,Karlsson, Anna,Balzarini, Jan,Van Calenbergh, Serge
experimental part, p. 2902 - 2912 (2010/08/06)
In an effort to increase the potency and selectivity of earlier identified substrate-based inhibitors of mitochondrial thymidine kinase 2 (TK-2), we now describe the synthesis of new thymidine analogues containing a 4- or 5-substituted 1,2,3-triazol-1-yl
