839-32-7Relevant academic research and scientific papers
Novel N-(phosphonomethyl) glycine derivatives: Design, characterization and biological activity
Naydenova, Emilia D.,Todorov, Petar T.,Topashka-Ancheva, Margarita N.,Momekov, Georgi Ts.,Yordanova, Tsvetelina Z.,Konstantinov, Spiro M.,Troev, Kolio D.
, p. 1199 - 1205 (2008/09/20)
A series of Cα,α-disubstituted cyclic derivatives of N-(phosphonomethyl) glycine have been synthesized and characterized. They exhibited moderate clastogenicity, low antiproliferative activity on mice bone marrow cells and well expressed cytotoxicity against human tumor cell lines. The 8- and 12-membered cyclic analogs proved superior to the remaining compounds and were found to trigger apoptotic cell death in DOHH-2 cells. The latter compound caused 50% inhibition of the viability of hemobastose-derived cell lines at concentrations ranging from 20 to 67 μM.
Aminoderivatives of cycloalkanespirohydantoins: Synthesis and biological activity
Naydenova, Emilia,Pencheva, Nevena,Popova, Julita,Stoyanov, Neyko,Lazarova, Maria,Aleksiev, Boris
, p. 189 - 194 (2007/10/03)
3-Aminocycloalkanespiro-5-hydantoins were synthesized and their biological activity was studied. In contrast to hydantoins, these compounds failed to induce either anticonvulsive effects in the central nervous system or inhibitory effects on cholinergic contractions in the enteric nervous system. However, they exerted well pronounced, atropinsensitive, contractile effects on the guinea-pig ileum longitudinal muscle preparations. Structure-activity relationships established allow the assumption that: (i) the reduction of the ring size in the molecule of the spirohydantoins leads to an increase in the potency of the respective analogue to induce contractile effect; (ii) the introduction of -NH2 in position 3 increases the ability of all the compounds studied to exert contractions; (iii) the enlargement of the ring leads to: (1) an increase of the degree of desensitization of the preparations; and (2) a decrease (except 1a) of the potency of the analogues to exert contractile effects.
Hydrogen-bonded tapes based on symmetrically substituted diketopiperazines: A robust structural motif for the engineering of molecular solids
Palacin, Serge,Chin, Donovan N.,Simanek, Eric E.,MacDonald, John C.,Whitesides, George M.,McBride, Mary T.,Palmore, G. Tayhas R.
, p. 11807 - 11816 (2007/10/03)
A series of eight symmetrically substituted diketopiperazines (DKPs) derived from 1-amino-1-carboxycycloalkanes (n = 3-7; 3,3,5,5-tetramethylcyclohexane; 4,4-dimethylcyclohexane; 2-indan) were synthesized and their crystal structures determined. In the solid state, all eight compounds form two pairs of hydrogen bonds with two adjacent molecules to form a one-dimensional structure that we refer to as 'tapes'. These molecules represent a range of volumes and shapes that contain a common molecular fragment (DKP ring). We examined this series of compounds with three objectives in mind: (i) to establish the ability of the hydrogen-bonded 'tape' motif to persist through these differences in volume and shape; (ii) to provide a series of structurally related compounds to use to test computational methods of predicting crystal structure from molecular structure; (iii) to search for qualitative correlations between molecular structure and crystal packing. All compounds form tapes and with one exception, all tapes pack with their long axes parallel. When viewed down their long axis, two types of tapes emerge: planar and nonplanar. The type of tape that forms reflects the conformation adapted by the DKP ring-planar or boat. Planar tapes form when the angle (α) between the two planes defined by the cis-amides in the DKP ring is 180°; nonplanar tapes form when α 180°. Five of the eight compounds studied form planar tapes, the remaining three compounds form nonplanar tapes. Despite the variability in volume and shape represented by this series of molecules, the persistence of the tape motif in their crystalline solids suggests that the hydrogen-bonding interactions between parallel alignment of tapes that pack in a manner that permits the interdigitation of substituents on adjacent tapes.
1,3-Diaminomethyl-hydantoin additives for lubricating oils
-
, (2008/06/13)
Lubricating oil compositions, comprising as additive, from 0.001 to 10% by weight, based on the weight of the total composition, of a 1- or 3-aminomethyl-hydantoin or a 1,3-diaminomethyl-hydantoin.
SYNTHESIS OF SOME I-AMINO ALICYCLIC CARBOXYLIC ACIDS AND THEIR DERIVATIVES
CREMLYN RJW,ELLAM RM,MITRA TK
, p. 218 - 220 (2007/10/08)
A number of isomeric 1-amino alicyclic carboxylic acids have been prepared via the Bucherer and Strecker routes. These amino acids have been converted into the corresponding copper complexes; p- toluenesulphonyl derivatives of the methyl esters of the amino acids have also been prepared. It is observed that the p- toluenesulphonyl derivatives of the methyl esters of Bucherer amino acids are generally obtained in higher yields as compared with the derivatives of Strecker amino acids, under identical experimental conditions.
