839-96-3

Upstream product

• 862-83-9 Diphenyl-(2-<6-methoxy-2-(1-phenyl-butyl)-phenyl>)-phosphin-methojodid 
• 71813-50-8 1-bromo-2-(but-3-enyl)benzene 
• 13397-98-3 1-bromo-2-butylbenzene 
• 766-85-8 3-methoxy-1-iodobenzene 
• 1438827-34-9 4,4,5,5-tetramethyl-2-(1-phenylbutyl)-1,3,2-dioxaborolane 
• 1438826-22-2 C₁₈H₃₁BO₂Si 
• 1438824-66-8 (2-butylphenyl)dimethylsilane 
• 3433-80-5 1-Bromo-2-bromomethyl-benzene 
• 108-86-1 bromobenzene 
• 591-50-4 iodobenzene 
• 768-56-9 4-Phenylbut-1-ene 

Relevant academic research and scientific papers

BH3 ? Me2S: An Alternative Hydride Source for NiH-Catalyzed Reductive Migratory Hydroarylation and Hydroalkenylation of Alkenes

Borane dimethylsulfide (BMS) was found to be an efficient hydride source for nickel-hydride catalyzed reductive migratory hydrofunctionalization reactions. Catalytic reductive migratory hydroarylation and migratory hydroalkenylation were achieved with BMS in high yields and with excellent regioselectivity. A large-scale experiment employing as little as 0.5 equivalents of BH3 ? Me2S as the hydride source delivered the desired migratory hydroarylation product in high yield and selectivity.

Rapid Access to Highly Functionalized Alkyl Boronates by NiH-Catalyzed Remote Hydroarylation of Boron-Containing Alkenes

The direct and selective functionalization of relatively simple and readily accessible precursors to produce highly functionalized alkyl boronates is a synthetically useful process. Herein we report a NiH-catalyzed remote hydroarylation process that can, through a synergistic combination of chain walking and subsequent cross-coupling, introduce an aryl group at the adjacent carbon atom of alkyl boronates under mild conditions. By means of a preliminary experiment with moderate enantioselectivity, it was shown that an asymmetric version could also be realized.

Iridium-catalyzed borylation of secondary benzylic C-H bonds directed by a hydrosilane

Most functionalizations of C-H bonds by main-group reagents occur at aryl or methyl groups. We describe a highly regioselective borylation of secondary benzylic C-H bonds catalyzed by an iridium precursor and 3,4,7,8-tetramethyl-1, 10-phenanthroline as the ligand. The reaction is directed to the benzylic position by a hydrosilyl substituent. This hydrosilyl directing group is readily deprotected or transformed to other functional groups after the borylation reaction, providing access to a diverse set of secondary benzylboronate esters by C-H borylation chemistry.