83908-12-7

Upstream product

• 13339-10-1 methyl 2-acetoxy-4-(bromomethyl)benzoate 
• 603-35-0 triphenylphosphine 

Downstream Products

• 1072937-67-7 methyl 4-[(E)-2-(5-bromo-3-methoxycarbonyl-4-methoxyphenyl)vinyl]-2-hydroxybenzoate 
• 1072937-66-6 methyl 4-[(E)-2-(5-bromo-3-methoxycarbonyl-4-methoxyphenyl)vinyl]-2-acetoxybenzoate 
• 1072937-53-1 C₁₆H₁₁BrO₆ 
• 1072937-65-5 methyl 4-[(E)-2-(3-methoxycarbonyl-4-methoxyphenyl)vinyl]-2-hydroxybenzoate 

Relevant academic research and scientific papers

Derivatives of 1,4-bis(3-hydroxycarbonyl-4-hydroxyl)styrylbenzene as PTP1B inhibitors with hypoglycemic activity

Disalicylic acid derivatives with stilbene and bis-styrylbenzene skeleton were synthesized as PTP1B inhibitors. The most potent in this series exhibited a submicromolar IC50 value. One of the compounds 7b was tested in an animal model for its efficacy as an anti-diabetic or an anti-obesity agent. In feeding compound 7b to diet-induced obese mice, no significant differences in weight gain and food consumption were observed between the drug-treated and the obese control mice. However, 7b significantly lowered the fasting glucose level and improved the glucose tolerance in the obesity-induced diabetic mice.