83921-02-2Relevant academic research and scientific papers
Biotransformation of α-terpineol by: Alternaria alternata
Cai, Le,Ding, Hao,Ding, Zhong-Tao,Duan, Wei-He,Mei, Rui-Feng,Shi, Ya-Xian,Zhang, Xiao-Ran
, p. 6491 - 6496 (2020/02/22)
α-Terpineol (1), the main volatile constituent in some traditional Chinese medicines, has been reported to be metabolized to 4R-oleuropeic acid by the larvae of common cutworms. The present study verified that α-terpineol could be converted to 4R-oleurope
New monoterpene glycosides and phenolic compounds from Distylium racemosum and their inhibitory activity against ribonuclease H
Kim, Jeong Ah,Yang, Seo Young,Wamiru, Anthony,McMahon, James B.,Le Grice, Stuart F.J.,Beutler, John A.,Kim, Young Ho
experimental part, p. 2840 - 2844 (2011/06/26)
Two new monoterpene glycosides, distyloside A-B (1-2), and a new megastigmane glucoside, iso-dihydrodendranthemoside A (3) were isolated from twigs and leaves of Distylium racemosum, along with five known phenolic compounds (4-8). The structures were established via spectroscopic techniques and chemical transformations, and the absolute stereochemistry of 3 was determined by Mosher's esterification. A homogeneous fluorescence resonance energy transfer (FRET) quenching assay was used to determine the inhibitory activity of isolates (1-8) on the ribonuclease H enzymes from HIV-1, 2, human, and Escherichia coli. Among them, 6″-O-galloylsalidroside (6) showed potent inhibitory effects with an IC50 value of 3.5 μM on HIV-2, and 1.7 μM on human RNase H, respectively.
THE ENANTIOSELECTIVE BIOTRANSFORMATION OF α-TERPINEOL AND ITS ACETATE WITH THE CULTURED CELLS OF NICOTIANA TABACUM
Suga, Takayuki,Hirata, Toshifumi,Lee, Ym Sook
, p. 1595 - 1598 (2007/10/02)
In the biotransformation of the enantiomers of p-ment-1-en-8-ol (α-terpineol) and 8-acetoxy-p-ment-1-ene (α-terpinyl acetate) with the cultured suspension cells of Nicotina tabacum, it was clarified that the cultured cells effected the hydroxylation at the 6-position of (4R)-(+)-enantiomer in preference to the (4S)-(-)-enantiomer, whereas the cells did the hydrolysis of the acetoxyl group and the hydroxylation of the ethylenic linkage of (4S)-(-)-α-terpinyl acetate in preference to the (4R)-(+)-enantiomer.
Cyclobutane Ring Opening of Pin-2(10)-ene with Mercury(II) Salts. A New, High-yield Synthesis of p-Mentha-1,8-dien-7-ol
Bluthe, Norbert,Ecoto, Jules,Fetizon, Marcel,Lazare, Sylvain
, p. 1747 - 1751 (2007/10/02)
The nucleophilic attack of pin-2(10)-ene-mercury(II) complex systems by water results in the opening of the four-membered ring leading to an allylic organomercury(II) derivative (11) with the p-menthane skeleton.This intermediate can be reduced by hydride to p-menth-1(2)-en-8-ol (6a) or can undergo an in situ SE2' elimination yielding p-menth-1(7)-en-8-ol (9a), in high yields. (-)-2,10-Epoxypinane (15) reacts with mercury(II) salts at room temperature, giving the diol (16) in a quantitative yield.Compound (16) is a suitable intermediate for convenient preparation of p-mentha-1,8-dien-7-ol (17) and its derivatives.
