83923-51-7Relevant articles and documents
NOVEL USE OF SUBSTITUTED CHROMAN-6-OLS
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Paragraph 0180-0183, (2021/02/05)
The present invention is directed towards the use of substituted chroman-6-ols of formula (I) wherein R1 and R2 are independently from each other H or C1-11-alkyl or (CH2)n—OH with n being an integer
A study of the reaction of different phenol substrates with nitric oxide and peroxynitrite
Yenes, Susana,Messeguer, Angel
, p. 14111 - 14122 (2007/10/03)
The reactivity of different phenol substrates with nitric oxide and peroxynitrite was investigated. In general, nitration is the major reaction with peroxynitrite, while reactions with aqueous solutions of nitric oxide led to mixtures of nitro and nitroso derivatives depending upon the phenol. Nitrosation occurs on phenol substrates bearing a free para- position with respect to the OH group with the exception of 1-naphthol, which afforded a 1:1 mixture of the 2- and the 4-nitroso derivatives. Chromans 7 and 8 showed the highest reactivity with peroxynitrite, which suggests that they can act as efficient scavengers of this toxic intermediate. In both cases the corresponding 5-nitro derivative was the only reaction product detected. Finally, the fact that chroman 8 reacts with nitric oxide to afford the p- quinone derivative 22a in 90% yield suggests that this antioxidant could also be of potential use as specific nitric oxide tracer in biological tissues.
Analogues of Antijuvenile Hormones
Anastasis, Panayiotis,Brown, Philip E.
, p. 2013 - 2018 (2007/10/02)
Several analogues of precocenes I and II have been synthsized, including derivatives of 6,7-dihydroxy-2,2-dimethylchromen, 7,8-dihydroxy-2,2-dimethylchromen, 7-hydroxy-2,2-dimethyl-6-nitrochromene, and 6-amino-7-hydroxy-2,2-dimethylchromen. 5,6-Dimethoxy-3,3-dimethylindene was also synthesized.Improved procedures for the dehydration of chroman-4-ols to chromens and for the reduction of chroman-4-ones to chroman-4-ols are reported.Analogues have been tested for activity in the brown planthopper Nilaparvatus lugens Stal.None had significant morphogenetic effects, but two possessed insecticidal activity and showed both antagonism and synergism when used in cojunction with permethrin.