839672-54-7

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 839672-52-5 KYS₀₅₀₄₄ 
• 839672-50-3 methyl 3-[2-((4-biphenyl)iminomethyleneamino)phenyl]acrylate 
• 51644-96-3 5-tert-butoxycarbonylamino-1-aminopentane 
• 92-95-5 4-biphenyl isocyanate 
• 462-94-2 1,5-diaminopentane 
• 138386-58-0 (2E)-3-{2-[(triphenylphosphoranylidene)amino]phenyl}-propenoic acid methyl ester 

Downstream Products

• 839672-58-1 KYS₀₅₀₄₈ 
• 839672-56-9 [3-biphenyl-4-yl-2-(5-tert-butoxycarbonylamino-pentylamino)-3,4-dihydro-quinazolin-4-yl]-acetic acid 

Relevant academic research and scientific papers

T-type Ca2+ channel blockers suppress the growth of human cancer cells

In order to further clarify the role of T-type Ca2+ channels in cell proliferation, we have measured the growth inhibition of human cancer cells by using our potent T-type Ca2+ channel blockers. As a result, KYS05090, a most potent T-type Ca2+ channel blocker, was found to be as potent as doxorubicin against some human cancer cells without acute toxicity. Therefore, this letter provides the biological results that T-type calcium channel is important in regulating the important cellular phenotype transition leading to cell proliferation, and thus novel T-type Ca2+ channel blocker presents new prospects for cancer treatment.

Synthesis and biological activity of 3,4-dihydroquinazolines for selective T-type Ca2+ channel blockers

We have synthesized 3,4-dihydroquinazoline derivatives for the potent and selective T-type Ca2+ channel blockers and evaluated for their inhibitory activities against two subtypes T-type Ca2+ channels and N-type Ca2+ chann