839719-22-1

Upstream product

• 103-72-0 phenyl isothiocyanate 
• 839719-21-0 4-methoxy-3-methylbenzo[1,2-b:5,4-b']difuran-2-carbohydrazide 
• 484-27-5 5-acetyl-4-methoxybenzofuran-6-ol 
• 839719-19-6 4-methoxy-3-methylbenzo[1,2-b:5,4-b']difuran-2-carboxylic acid 
• 839719-20-9 4-methoxy-3-methylbenzo[1,2-b:5,4-b']difuran-2-carboxylic acid ethyl ester 
• 839719-18-5 (5-acetyl-4-methoxy-benzofuran-6-yloxy)acetic acid ethyl ester 

Relevant academic research and scientific papers

Synthesis of benzo[1,2-b: 5,4-b′]-difuranyl-triazoles, -oxadiazoles, -thiazolidinones, -thiadiazoles, and the use of DNA in evaluation of their biological activity

Benzo[1,2-b:5,4-b′]difuran-2-carbohydrazides 5a,b were reacted with aryl or alkyl isothiocyanates to give the corresponding thiosemicarbazides 6a-h. Cyclization of the substituted thiosemicarbazides with sodium hydroxide led to the formation of benzo[1,2-b:5,4-b′]difuranyl-1,3,4-triazoles 7a-f. Desulfurization of thiosemicarbazides by mercuric oxide gave benzo[1,2-b:5,4-b′]difuronyl-1,3,4-oxadiazoles 8a-f. Treatment of thiosemicarbazides with ethyl bromoacetate or α-bromopropionic acid yielded benzo[1,2-b:5,4-b′]difuranyl-carbonyl-hydrazono-4-thiazolidinones 9a-f and 10a-f, respectively. Furthermore, the reaction of the thiosemicarbazides with phosphorus oxychloride gave benzo[1,2-b:5,4-b′] difuranyl-1,3,4-thiadiazoles 11a-f. Some compounds in this study were biologically evaluated for their ability to bind to DNA.